DegronMD

Uniprot ID: C9JTQ0

Source protein: Ankyrin repeat domain-containing protein 63

Source gene: ANKRD63

Class: LIG_APCC_ABBA_1

Location: 312:317

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9864

ASA_SCORE: 74.4

COIL: 0.908

CONS_SCORE: 0.9717

DSS_SCORE: 0.7527

HELIX: 0.025

FCONS_SCORE: 1.0857

RIG_SCORE: 0.5671

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L305S	DO233869	GACA	ICGC	LSPHPE	LIG_APCC_ABBA_1	0.1389
p.P309L	DO222727	MELA	ICGC	LSPHPE	LIG_APCC_ABBA_1	0.25
p.P314L	DO222875	MELA	ICGC	LSPHPE	LIG_APCC_ABBA_1	0.6471
p.P320S	DO232519	PBCA	ICGC	LSPHPE	LIG_APCC_ABBA_1	0.25
p.P320L	DO229216	THCA	ICGC	LSPHPE	LIG_APCC_ABBA_1	0.25
p.P302T	DO229250	THCA	ICGC	LSPHPE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
C9JTQ0	Ankyrin repeat domain-containing protein 63	LIG_APCC_ABBA_1	312:317	LSPHPE	APC,CDC20,FZR1	0.9864	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons