DegronMD

Uniprot ID: Q92777

Source protein: Synapsin-2

Source gene: SYN2

Class: DEG_SCF_FBW7_1

Location: 418:425

E3 ligase: FBXW7

DEGRON score: 0.9778

ASA_SCORE: 86.075

COIL: 0.8299

CONS_SCORE: 0.3358

DSS_SCORE: 0.5877

HELIX: 0.1451

FCONS_SCORE: 0.8198

RIG_SCORE: 0.695

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P422T	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	LSRTPALS	DEG_SCF_FBW7_1	0.7031
p.P422T	NCI-H23	lung	COSMIC	LSRTPALS	DEG_SCF_FBW7_1	0.7031
p.Q433H	SIDM00826	Colorectal Carcinoma	GDSC	LSRTPALS	DEG_SCF_FBW7_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92777	Synapsin-2	DEG_SCF_FBW7_1	418:425	LSRTPALS	FBXW7	0.9778	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons