DegronMD

Uniprot ID: C9J069

Source protein: Apical junction component 1 homolog

Source gene: AJM1

Class: DEG_SCF_FBW7_1

Location: 235:242

E3 ligase: FBXW7

DEGRON score: 0.9938

ASA_SCORE: 83.9625

COIL: 0.9566

CONS_SCORE: 0.7577

DSS_SCORE: 0.5131

HELIX: 0.0225

FCONS_SCORE: 1.0889

RIG_SCORE: 0.6322

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S236W	SIDM00614	Hepatocellular Carcinoma	GDSC	LSRTPTPS	DEG_SCF_FBW7_1	0.6763
p.S236W	JHH-7	liver	COSMIC	LSRTPTPS	DEG_SCF_FBW7_1	0.6763
p.T240A	SIDM00451	T-Lymphoblastic Leukemia	GDSC	LSRTPTPS	DEG_SCF_FBW7_1	0.6028
p.T240A	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LSRTPTPS	DEG_SCF_FBW7_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
C9J069	Apical junction component 1 homolog	DEG_SCF_FBW7_1	235:242	LSRTPTPS	FBXW7	0.9938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons