DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 4838:4845

E3 ligase: FBXW7

DEGRON score: 0.9606

ASA_SCORE: 82.125

COIL: 0.8859

CONS_SCORE: 0.282

DSS_SCORE: 0.4904

HELIX: 0.0206

FCONS_SCORE: 1.0909

RIG_SCORE: 0.7488

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T4845N	TCGA-05-4417	LUAD	TCGA	LSSTPGTT	DEG_SCF_FBW7_1	0.7055
p.W4846R	TCGA-05-4417	LUAD	TCGA	LSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.T4829P	TCGA-AZ-4315	COAD	TCGA	LSSTPGTT	DEG_SCF_FBW7_1	0.0833
p.T4835M	TCGA-AZ-6601	COAD	TCGA	LSSTPGTT	DEG_SCF_FBW7_1	0.25
p.G4843E	TCGA-CV-7263	HNSC	TCGA	LSSTPGTT	DEG_SCF_FBW7_1	0.6087
p.T4829I	TCGA-D3-A2JE	SKCM	TCGA	LSSTPGTT	DEG_SCF_FBW7_1	0.0833
p.P4851L	TCGA-FP-7829	STAD	TCGA	LSSTPGTT	DEG_SCF_FBW7_1	0.1667
p.P4851L	TCGA-HF-7132	STAD	TCGA	LSSTPGTT	DEG_SCF_FBW7_1	0.1667
p.P4851L	SIDM00780	Colorectal Carcinoma	GDSC	LSSTPGTT	DEG_SCF_FBW7_1	0.1667
p.P4851L	ACH-000967	Colon/Colorectal Cancer	CCLE	LSSTPGTT	DEG_SCF_FBW7_1	0.1667
p.S4839Y	TCGA-LN-A9FP	ESCA	TCGA	LSSTPGTT	DEG_SCF_FBW7_1	0.6009
p.T4838M	DO8119	COAD	ICGC	LSSTPGTT	DEG_SCF_FBW7_1	0.7423
p.T4832P	DO8842	COAD	ICGC	LSSTPGTT	DEG_SCF_FBW7_1	0.1667
p.G4846E	DO14398	HNSC	ICGC	LSSTPGTT	DEG_SCF_FBW7_1	0.3056
p.A4833S	DO229018	LICA	ICGC	LSSTPGTT	DEG_SCF_FBW7_1	0.1944
p.W4849R	DO23570	LUAD	ICGC	LSSTPGTT	DEG_SCF_FBW7_1	0.2222
p.T4848N	DO23570	LUAD	ICGC	LSSTPGTT	DEG_SCF_FBW7_1	0.25
p.S4842F	DO222908	MELA	ICGC	LSSTPGTT	DEG_SCF_FBW7_1	0.7982
p.T4828P	DO229453	SKCA	ICGC	LSSTPGTT	DEG_SCF_FBW7_1	0.0556
p.T4832I	DO219476	SKCM	ICGC	LSSTPGTT	DEG_SCF_FBW7_1	0.1667
p.P4854L	DO38308	STAD	ICGC	LSSTPGTT	DEG_SCF_FBW7_1	0.0833
p.P4854L	DO38214	STAD	ICGC	LSSTPGTT	DEG_SCF_FBW7_1	0.0833
p.S4834F	SIDM00583	Pancreatic Carcinoma	GDSC	LSSTPGTT	DEG_SCF_FBW7_1	0.2222
p.S4834F	ACH-001107	Pancreatic Cancer	CCLE	LSSTPGTT	DEG_SCF_FBW7_1	0.2222
p.S4834F	KP-1N	pancreas	COSMIC	LSSTPGTT	DEG_SCF_FBW7_1	0.2222
p.S4839F	ACH-001028	Rhabdoid	CCLE	LSSTPGTT	DEG_SCF_FBW7_1	0.6871

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4838:4845	LSSTPGTT	FBXW7	0.9606	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSSTPGTT

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of LSSTPGTT