DegronMD

Uniprot ID: O60806

Source protein: T-box transcription factor TBX19

Source gene: TBX19

Class: DEG_SCF_FBW7_1

Location: 328:335

E3 ligase: FBXW7

DEGRON score: 0.9095

ASA_SCORE: 60.4875

COIL: 0.8453

CONS_SCORE: 0.4462

DSS_SCORE: 0.392

HELIX: 0.1255

FCONS_SCORE: 1.0011

RIG_SCORE: 0.653

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S329F	TCGA-BF-AAP2	SKCM	TCGA	LSSTPHAS	DEG_SCF_FBW7_1	0.6871
p.S329F	DO219466	SKCM	ICGC	LSSTPHAS	DEG_SCF_FBW7_1	0.6871
p.S335G	TCGA-BR-8060	STAD	TCGA	LSSTPHAS	DEG_SCF_FBW7_1	0.6993
p.S335G	DO38205	STAD	ICGC	LSSTPHAS	DEG_SCF_FBW7_1	0.6993
p.S327F	TCGA-FW-A3R5	SKCM	TCGA	LSSTPHAS	DEG_SCF_FBW7_1	0.3056
p.S327F	DO37406	SKCM	ICGC	LSSTPHAS	DEG_SCF_FBW7_1	0.3056
p.S335I	DO222404	BTCA	ICGC	LSSTPHAS	DEG_SCF_FBW7_1	0.7341
p.P332S	DO229502	SKCA	ICGC	LSSTPHAS	DEG_SCF_FBW7_1	0.6752
p.N343Y	SIDM00962	Chronic Myelogenous Leukemia	GDSC	LSSTPHAS	DEG_SCF_FBW7_1	0.1111
p.N343Y	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	LSSTPHAS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60806	T-box transcription factor TBX19	DEG_SCF_FBW7_1	328:335	LSSTPHAS	FBXW7	0.9095	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons