DegronMD

Uniprot ID: Q8NHW3

Source protein: Transcription factor MafA

Source gene: MAFA

Class: DEG_SCF_FBW7_1

Location: 50:57

E3 ligase: FBXW7

DEGRON score: 0.9955

ASA_SCORE: 83.4125

COIL: 0.9461

CONS_SCORE: 0.4701

DSS_SCORE: 0.4967

HELIX: 0.0229

FCONS_SCORE: 1.0325

RIG_SCORE: 0.5996

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F41Y	TCGA-DD-AACT	LIHC	TCGA	LSSTPLST	DEG_SCF_FBW7_1	0.0833
p.F41Y	DO219563	LIHC	ICGC	LSSTPLST	DEG_SCF_FBW7_1	0.0833
p.S56N	DO233693	GACA	ICGC	LSSTPLST	DEG_SCF_FBW7_1	0.5958
p.S52L	DO229229	THCA	ICGC	LSSTPLST	DEG_SCF_FBW7_1	0.6556
p.P66S	SIDM00120	Prostate Carcinoma	GDSC	LSSTPLST	DEG_SCF_FBW7_1	0.0833
p.P66S	ACH-000979	Prostate Cancer	CCLE	LSSTPLST	DEG_SCF_FBW7_1	0.0833
p.P54S	SIDM01175	Other Sarcomas	GDSC	LSSTPLST	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NHW3	Transcription factor MafA	DEG_SCF_FBW7_1	50:57	LSSTPLST	FBXW7	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons