DegronMD

Uniprot ID: Q8N201

Source protein: Integrator complex subunit 1

Source gene: INTS1

Class: DEG_SCF_FBW7_1

Location: 80:87

E3 ligase: FBXW7

DEGRON score: 0.9987

ASA_SCORE: 73.0375

COIL: 0.903

CONS_SCORE: 0.3003

DSS_SCORE: 0.4715

HELIX: 0.0504

FCONS_SCORE: 0.9966

RIG_SCORE: 0.6713

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P85H	TCGA-A5-A0GB	UCEC	TCGA	LSSTPPLS	DEG_SCF_FBW7_1	0.6583
p.R77H	TCGA-A5-A1OF	UCEC	TCGA	LSSTPPLS	DEG_SCF_FBW7_1	0.25
p.R77H	SIDM01617	Endometrial Carcinoma	GDSC	LSSTPPLS	DEG_SCF_FBW7_1	0.25
p.S82P	TCGA-AG-3898	READ	TCGA	LSSTPPLS	DEG_SCF_FBW7_1	0.6752
p.L92M	TCGA-B5-A1MX	UCEC	TCGA	LSSTPPLS	DEG_SCF_FBW7_1	0.1944
p.S81F	TCGA-C8-A274	BRCA	TCGA	LSSTPPLS	DEG_SCF_FBW7_1	0.7982
p.S81F	DO229456	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7982
p.L89F	DO234202	ESAD	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.2778
p.C78G	DO23342	LINC	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.2778
p.P80L	DO229177	LMS	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO220851	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO220877	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO220883	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO220886	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO220891	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO220890	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO220897	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO220899	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO220900	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO220906	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO220911	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO222402	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO222696	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO222880	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO232061	ORCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO229446	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO229459	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO229453	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO218900	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO218863	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO218849	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO229502	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO37750	SKCM	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO37418	SKCM	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO37474	SKCM	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO37435	SKCM	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO37432	SKCM	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80L	DO50291	SKCM	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7582
p.P80S	DO229177	LMS	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.6752
p.P80S	DO220851	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.6752
p.P80S	DO220878	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.6752
p.P80S	DO220891	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.6752
p.P80S	DO220896	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.6752
p.P80S	DO220906	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.6752
p.P80S	DO220911	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.6752
p.P80S	DO222521	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.6752
p.P80S	DO219878	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.6752
p.P80S	DO229446	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.6752
p.P80S	DO229453	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.6752
p.P80S	DO229456	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.6752
p.P80S	DO218863	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.6752
p.P80S	DO218850	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.6752
p.P80S	DO47255	SKCM	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.6752
p.P80S	DO37474	SKCM	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.6752
p.P80S	DO37432	SKCM	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.6752
p.P80F	DO220851	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7897
p.P80F	DO220906	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7897
p.P80F	DO220911	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7897
p.G85E	DO222731	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7199
p.G85E	DO37425	SKCM	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.7199
p.P75L	DO218900	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	0.6389
p.A88V	SIDM01194	Hepatocellular Carcinoma	GDSC	LSSTPPLS	DEG_SCF_FBW7_1	0.3056
p.A88V	ACH-000420	Liver Cancer	CCLE	LSSTPPLS	DEG_SCF_FBW7_1	0.3056
p.A88V	SNU-449	liver	COSMIC	LSSTPPLS	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSSTPPLS

Degron related mutations and impact score

Drug responses associated with INTS1 mutations

All proteins holding degron of LSSTPPLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N201	Integrator complex subunit 1	DEG_SCF_FBW7_1	80:87	LSSTPPLS	FBXW7	0.9987	More...