DegronMD - Q8N201(INTS1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T781I	TCGA-A5-A0G1	UCEC	TCGA	NNYSYPP	CBL_PTK	773:779	Mutation rewiring degron network	0.2778
p.P85H	TCGA-A5-A0GB	UCEC	TCGA	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.6583
p.R77H	TCGA-A5-A1OF	UCEC	TCGA	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation rewiring degron network	0.25
p.R77H	SIDM01617	Endometrial Carcinoma	GDSC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation rewiring degron network	0.25
p.S82P	TCGA-AG-3898	READ	TCGA	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.6752
p.L92M	TCGA-B5-A1MX	UCEC	TCGA	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation rewiring degron network	0.1944
p.M767T	TCGA-BS-A0U8	UCEC	TCGA	NNYSYPP	CBL_PTK	773:779	Mutation rewiring degron network	0.1667
p.S81F	TCGA-C8-A274	BRCA	TCGA	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7982
p.S81F	DO229456	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7982
p.Y775C	TCGA-DK-A1A7	BLCA	TCGA	NNYSYPP	CBL_PTK	773:779	Mutation altering degron motif	0.7087
p.P779S	TCGA-E6-A2P9	UCEC	TCGA	NNYSYPP	CBL_PTK	773:779	Mutation altering degron motif	0.6752
p.P779S	TCGA-EC-A24G	UCEC	TCGA	NNYSYPP	CBL_PTK	773:779	Mutation altering degron motif	0.6752
p.D784N	TCGA-E8-A418	THCA	TCGA	NNYSYPP	CBL_PTK	773:779	Mutation rewiring degron network	0.1944
p.S776F	TCGA-GU-AATP	BLCA	TCGA	NNYSYPP	CBL_PTK	773:779	Mutation altering degron motif	0.7982
p.S776F	ACH-001134	Lymphoma	CCLE	NNYSYPP	CBL_PTK	773:779	Mutation altering degron motif	0.7982
p.R788W	TCGA-J9-A52C	PRAD	TCGA	NNYSYPP	CBL_PTK	773:779	Mutation rewiring degron network	0.0833
p.R788Q	TCGA-KQ-A41N	BLCA	TCGA	NNYSYPP	CBL_PTK	773:779	Mutation rewiring degron network	0.0833
p.R953C	TCGA-VQ-A8PP	STAD	TCGA	QRQLLGRLQ	DEG_APCC_DBOX_1	947:955	Mutation altering degron motif	0.719
p.M782I	DO51732	COAD	ICGC	NNYSYPP	CBL_PTK	773:779	Mutation rewiring degron network	0.25
p.R783S	DO10582	COAD	ICGC	NNYSYPP	CBL_PTK	773:779	Mutation rewiring degron network	0.2222
p.R783S	DO229015	LICA	ICGC	NNYSYPP	CBL_PTK	773:779	Mutation rewiring degron network	0.2222
p.L89F	DO234202	ESAD	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation rewiring degron network	0.2778
p.L964M	DO233207	GACA	ICGC	QRQLLGRLQ	DEG_APCC_DBOX_1	947:955	Mutation rewiring degron network	0.0833
p.R764S	DO228948	LICA	ICGC	NNYSYPP	CBL_PTK	773:779	Mutation substituting flanking lysine	0.1944
p.S963R	DO229028	LICA	ICGC	QRQLLGRLQ	DEG_APCC_DBOX_1	947:955	Mutation rewiring degron network	0.1111
p.C78G	DO23342	LINC	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation rewiring degron network	0.2778
p.P80L	DO229177	LMS	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO220851	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO220877	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO220883	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO220886	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO220891	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO220890	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO220897	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO220899	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO220900	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO220906	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO220911	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO222402	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO222696	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO222880	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO232061	ORCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO229446	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO229459	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO229453	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO218900	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO218863	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO218849	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO229502	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO37750	SKCM	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO37418	SKCM	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO37474	SKCM	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO37435	SKCM	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO37432	SKCM	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80L	DO50291	SKCM	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7582
p.P80S	DO229177	LMS	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.6752
p.P80S	DO220851	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.6752
p.P80S	DO220878	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.6752
p.P80S	DO220891	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.6752
p.P80S	DO220896	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.6752
p.P80S	DO220906	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.6752
p.P80S	DO220911	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.6752
p.P80S	DO222521	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.6752
p.P80S	DO219878	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.6752
p.P80S	DO229446	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.6752
p.P80S	DO229453	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.6752
p.P80S	DO229456	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.6752
p.P80S	DO218863	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.6752
p.P80S	DO218850	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.6752
p.P80S	DO47255	SKCM	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.6752
p.P80S	DO37474	SKCM	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.6752
p.P80S	DO37432	SKCM	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.6752
p.G939V	DO45378	LUAD	ICGC	QRQLLGRLQ	DEG_APCC_DBOX_1	947:955	Mutation substituting flanking lysine	0.2222
p.K947R	DO27660	LUSC	ICGC	QRQLLGRLQ	DEG_APCC_DBOX_1	947:955	Mutation altering degron motif	0.7237
p.P80F	DO220851	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7897
p.P80F	DO220906	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7897
p.P80F	DO220911	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7897
p.G85E	DO222731	MELA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7199
p.G85E	DO37425	SKCM	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.7199
p.V786L	DO232835	NACA	ICGC	NNYSYPP	CBL_PTK	773:779	Mutation rewiring degron network	0.1389
p.R783C	DO227520	ORCA	ICGC	NNYSYPP	CBL_PTK	773:779	Mutation rewiring degron network	0.2222
p.R783C	DO38404	STAD	ICGC	NNYSYPP	CBL_PTK	773:779	Mutation rewiring degron network	0.2222
p.V774A	DO36556	READ	ICGC	NNYSYPP	CBL_PTK	773:779	Mutation altering degron motif	0.6936
p.P75L	DO218900	SKCA	ICGC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation blocking phosphorylation signal	0.6389
p.R941W	SIDM02035	Colorectal Carcinoma	GDSC	QRQLLGRLQ	DEG_APCC_DBOX_1	947:955	Mutation rewiring degron network	0.1667
p.L950V	SIDM00602	Gastric Carcinoma	GDSC	QRQLLGRLQ	DEG_APCC_DBOX_1	947:955	Mutation altering degron motif	0.5654
p.L950V	ACH-000665	Lung Cancer	CCLE	QRQLLGRLQ	DEG_APCC_DBOX_1	947:955	Mutation altering degron motif	0.5654
p.A88V	SIDM01194	Hepatocellular Carcinoma	GDSC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation rewiring degron network	0.3056
p.A88V	ACH-000420	Liver Cancer	CCLE	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation rewiring degron network	0.3056
p.A88V	SNU-449	liver	COSMIC	LSSTPPLS	DEG_SCF_FBW7_1	80:87	Mutation rewiring degron network	0.3056
p.R953H	ACH-000955	Colon/Colorectal Cancer	CCLE	QRQLLGRLQ	DEG_APCC_DBOX_1	947:955	Mutation altering degron motif	0.7133

DegronMD: protein-targeted degradation, mutation and drug response to degrons

INTS1

UniProt ID: Q8N201

Entrez ID: 26173

Protein name: Integrator complex subunit 1 (Int1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for INTS1 in