DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
NNYSYPP
Uniprot ID:
Q8N201
Source protein:
Integrator complex subunit 1
Source gene:
INTS1
Class:
CBL_PTK
Location:
773:779
E3 ligase:
CBL
DEGRON score:
0.8561
ASA_SCORE:
69.8714
COIL:
0.8896
CONS_SCORE:
0.452
DSS_SCORE:
0.3094
HELIX:
0.0697
FCONS_SCORE:
1.0171
RIG_SCORE:
0.7605
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T781I
TCGA-A5-A0G1
UCEC
TCGA
NNYSYPP
CBL_PTK
0.2778
p.M767T
TCGA-BS-A0U8
UCEC
TCGA
NNYSYPP
CBL_PTK
0.1667
p.Y775C
TCGA-DK-A1A7
BLCA
TCGA
NNYSYPP
CBL_PTK
0.7087
p.P779S
TCGA-E6-A2P9
UCEC
TCGA
NNYSYPP
CBL_PTK
0.6752
p.P779S
TCGA-EC-A24G
UCEC
TCGA
NNYSYPP
CBL_PTK
0.6752
p.D784N
TCGA-E8-A418
THCA
TCGA
NNYSYPP
CBL_PTK
0.1944
p.S776F
TCGA-GU-AATP
BLCA
TCGA
NNYSYPP
CBL_PTK
0.7982
p.S776F
ACH-001134
Lymphoma
CCLE
NNYSYPP
CBL_PTK
0.7982
p.R788W
TCGA-J9-A52C
PRAD
TCGA
NNYSYPP
CBL_PTK
0.0833
p.R788Q
TCGA-KQ-A41N
BLCA
TCGA
NNYSYPP
CBL_PTK
0.0833
p.M782I
DO51732
COAD
ICGC
NNYSYPP
CBL_PTK
0.25
p.R783S
DO10582
COAD
ICGC
NNYSYPP
CBL_PTK
0.2222
p.R783S
DO229015
LICA
ICGC
NNYSYPP
CBL_PTK
0.2222
p.R764S
DO228948
LICA
ICGC
NNYSYPP
CBL_PTK
0.1944
p.V786L
DO232835
NACA
ICGC
NNYSYPP
CBL_PTK
0.1389
p.R783C
DO227520
ORCA
ICGC
NNYSYPP
CBL_PTK
0.2222
p.R783C
DO38404
STAD
ICGC
NNYSYPP
CBL_PTK
0.2222
p.V774A
DO36556
READ
ICGC
NNYSYPP
CBL_PTK
0.6936
Drug responses associated with INTS1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NNYSYPP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N201
Integrator complex subunit 1
CBL_PTK
773:779
NNYSYPP
CBL
0.8561
More...
