DegronMD

Uniprot ID: Q8N201

Source protein: Integrator complex subunit 1

Source gene: INTS1

Class: DEG_APCC_DBOX_1

Location: 947:955

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6728

ASA_SCORE: 65.3444

COIL: 0.0171

CONS_SCORE: 0.4055

DSS_SCORE: 0.4325

HELIX: 0.9828

FCONS_SCORE: 1.2634

RIG_SCORE: 0.7618

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R953C	TCGA-VQ-A8PP	STAD	TCGA	QRQLLGRLQ	DEG_APCC_DBOX_1	0.719
p.L964M	DO233207	GACA	ICGC	QRQLLGRLQ	DEG_APCC_DBOX_1	0.0833
p.S963R	DO229028	LICA	ICGC	QRQLLGRLQ	DEG_APCC_DBOX_1	0.1111
p.G939V	DO45378	LUAD	ICGC	QRQLLGRLQ	DEG_APCC_DBOX_1	0.2222
p.K947R	DO27660	LUSC	ICGC	QRQLLGRLQ	DEG_APCC_DBOX_1	0.7237
p.R941W	SIDM02035	Colorectal Carcinoma	GDSC	QRQLLGRLQ	DEG_APCC_DBOX_1	0.1667
p.L950V	SIDM00602	Gastric Carcinoma	GDSC	QRQLLGRLQ	DEG_APCC_DBOX_1	0.5654
p.L950V	ACH-000665	Lung Cancer	CCLE	QRQLLGRLQ	DEG_APCC_DBOX_1	0.5654
p.R953H	ACH-000955	Colon/Colorectal Cancer	CCLE	QRQLLGRLQ	DEG_APCC_DBOX_1	0.7133

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N201	Integrator complex subunit 1	DEG_APCC_DBOX_1	947:955	QRQLLGRLQ	APC,CDC20,FZR1	0.6728	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons