DegronMD

Uniprot ID: Q5XUX1

Source protein: F-box/WD repeat-containing protein 9

Source gene: FBXW9

Class: DEG_SCF_FBW7_1

Location: 53:59

E3 ligase: FBXW7

DEGRON score: 0.9929

ASA_SCORE: 54.4714

COIL: 0.8881

CONS_SCORE: 0.3573

DSS_SCORE: 0.5955

HELIX: 0.0381

FCONS_SCORE: 1.0462

RIG_SCORE: 0.5927

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R66W	TCGA-CJ-5686	KIRC	TCGA	LSTPAAS	DEG_SCF_FBW7_1	0.1389
p.G44W	TCGA-HR-A2OG	SKCM	TCGA	LSTPAAS	DEG_SCF_FBW7_1	0.0833
p.A58T	DO233676	GACA	ICGC	LSTPAAS	DEG_SCF_FBW7_1	0.6028
p.H57Q	DO228986	LICA	ICGC	LSTPAAS	DEG_SCF_FBW7_1	0.7582
p.H65Q	DO229031	LICA	ICGC	LSTPAAS	DEG_SCF_FBW7_1	0.1667
p.A58E	DO229045	LICA	ICGC	LSTPAAS	DEG_SCF_FBW7_1	0.659
p.R56W	DO38711	STAD	ICGC	LSTPAAS	DEG_SCF_FBW7_1	0.8634
p.D64N	DO229250	THCA	ICGC	LSTPAAS	DEG_SCF_FBW7_1	0.1944
p.R49H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LSTPAAS	DEG_SCF_FBW7_1	0.2222
p.R49H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LSTPAAS	DEG_SCF_FBW7_1	0.2222
p.R49H	ACH-000995	Leukemia	CCLE	LSTPAAS	DEG_SCF_FBW7_1	0.2222
p.R49H	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LSTPAAS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5XUX1	F-box/WD repeat-containing protein 9	DEG_SCF_FBW7_1	53:59	LSTPAAS	FBXW7	0.9929	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons