DegronMD

Uniprot ID: A1L4H1

Source protein: Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

Source gene: SSC5D

Class: DEG_SCF_FBW7_1

Location: 1071:1077

E3 ligase: FBXW7

DEGRON score: 0.9905

ASA_SCORE: 73.7857

COIL: 0.8896

CONS_SCORE: 0.4717

DSS_SCORE: 0.6005

HELIX: 0.0366

FCONS_SCORE: 1.213

RIG_SCORE: 0.6311

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1074L	TCGA-2W-A8YY	CESC	TCGA	LSTPDSS	DEG_SCF_FBW7_1	0.7582
p.P1074L	DO223732	CESC	ICGC	LSTPDSS	DEG_SCF_FBW7_1	0.7582
p.S1077R	TCGA-5P-A9KA	KIRP	TCGA	LSTPDSS	DEG_SCF_FBW7_1	0.7427
p.S1077R	DO223953	KIRP	ICGC	LSTPDSS	DEG_SCF_FBW7_1	0.7427

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SCF_FBW7_1	1071:1077	LSTPDSS	FBXW7	0.9905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons