DegronMD

Uniprot ID: P46821

Source protein: Microtubule-associated protein 1B

Source gene: MAP1B

Class: DEG_SCF_FBW7_2

Location: 1851:1857

E3 ligase: FBXW7

DEGRON score: 0.9934

ASA_SCORE: 89.4714

COIL: 0.9309

CONS_SCORE: 0.4584

DSS_SCORE: 0.5648

HELIX: 0.0476

FCONS_SCORE: 1.0111

RIG_SCORE: 0.6645

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M1841L	TCGA-18-3409	LUSC	TCGA	LSTPGLE	DEG_SCF_FBW7_2	0.0556
p.M1841L	DO26444	LUSC	ICGC	LSTPGLE	DEG_SCF_FBW7_2	0.0556
p.P1854H	TCGA-A6-3809	COAD	TCGA	LSTPGLE	DEG_SCF_FBW7_2	0.7694
p.P1854H	DO8722	COAD	ICGC	LSTPGLE	DEG_SCF_FBW7_2	0.7694
p.P1865S	DO229456	SKCA	ICGC	LSTPGLE	DEG_SCF_FBW7_2	0.1111
p.P1865L	DO229456	SKCA	ICGC	LSTPGLE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46821	Microtubule-associated protein 1B	DEG_SCF_FBW7_2	1851:1857	LSTPGLE	FBXW7	0.9934	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons