DegronMD

Uniprot ID: Q9UPW0

Source protein: Forkhead box protein J3

Source gene: FOXJ3

Class: DEG_SCF_FBW7_1

Location: 576:582

E3 ligase: FBXW7

DEGRON score: 0.9949

ASA_SCORE: 84.1714

COIL: 0.9433

CONS_SCORE: 0.4243

DSS_SCORE: 0.6601

HELIX: 0.0403

FCONS_SCORE: 1.1371

RIG_SCORE: 0.5828

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A589V	TCGA-AX-A0J1	UCEC	TCGA	LSTPGTT	DEG_SCF_FBW7_1	0.1389
p.H586Y	TCGA-CV-7235	HNSC	TCGA	LSTPGTT	DEG_SCF_FBW7_1	0.2222
p.P579A	TCGA-DK-A1AC	BLCA	TCGA	LSTPGTT	DEG_SCF_FBW7_1	0.7503
p.R570W	DO227906	COCA	ICGC	LSTPGTT	DEG_SCF_FBW7_1	0.1667
p.R570W	DO234462	ESAD	ICGC	LSTPGTT	DEG_SCF_FBW7_1	0.1667
p.R570W	DO35083	PACA	ICGC	LSTPGTT	DEG_SCF_FBW7_1	0.1667
p.R570W	DO228138	PBCA	ICGC	LSTPGTT	DEG_SCF_FBW7_1	0.1667
p.R570W	DO38487	STAD	ICGC	LSTPGTT	DEG_SCF_FBW7_1	0.1667
p.P575T	DO228924	LICA	ICGC	LSTPGTT	DEG_SCF_FBW7_1	0.3056
p.D583H	DO219217	LUSC	ICGC	LSTPGTT	DEG_SCF_FBW7_1	0.3056
p.S572F	DO50287	SKCM	ICGC	LSTPGTT	DEG_SCF_FBW7_1	0.2222
p.R571C	DO48032	STAD	ICGC	LSTPGTT	DEG_SCF_FBW7_1	0.1944
p.R571C	DO40978	UCEC	ICGC	LSTPGTT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPW0	Forkhead box protein J3	DEG_SCF_FBW7_1	576:582	LSTPGTT	FBXW7	0.9949	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons