DegronMD

Uniprot ID: Q4KMG0

Source protein: Cell adhesion molecule-related/down-regulated by oncogenes

Source gene: CDON

Class: DEG_SCF_FBW7_1

Location: 939:945

E3 ligase: FBXW7

DEGRON score: 0.7906

ASA_SCORE: 74.7143

COIL: 0.914

CONS_SCORE: 0.4805

DSS_SCORE: 0.5426

HELIX: 0.0411

FCONS_SCORE: 1.1269

RIG_SCORE: 0.6493

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P942H	TCGA-18-3407	LUSC	TCGA	LSTPPNS	DEG_SCF_FBW7_1	0.7694
p.G947V	TCGA-B5-A11E	UCEC	TCGA	LSTPPNS	DEG_SCF_FBW7_1	0.2778
p.S945Y	TCGA-BK-A6W3	UCEC	TCGA	LSTPPNS	DEG_SCF_FBW7_1	0.8231
p.S945Y	SIDM00534	Colorectal Carcinoma	GDSC	LSTPPNS	DEG_SCF_FBW7_1	0.8231
p.S945Y	SIDM01611	Endometrial Carcinoma	GDSC	LSTPPNS	DEG_SCF_FBW7_1	0.8231
p.S945Y	ACH-000986	Colon/Colorectal Cancer	CCLE	LSTPPNS	DEG_SCF_FBW7_1	0.8231
p.S945Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	LSTPPNS	DEG_SCF_FBW7_1	0.8231
p.S945Y	HT-115	large_intestine	COSMIC	LSTPPNS	DEG_SCF_FBW7_1	0.8231
p.T941A	TCGA-BR-4184	STAD	TCGA	LSTPPNS	DEG_SCF_FBW7_1	0.825
p.D938Y	TCGA-E6-A1LX	UCEC	TCGA	LSTPPNS	DEG_SCF_FBW7_1	0.3056
p.P943T	TCGA-E8-A2EA	THCA	TCGA	LSTPPNS	DEG_SCF_FBW7_1	0.5919
p.A955V	SIDM02015	Colorectal Carcinoma	GDSC	LSTPPNS	DEG_SCF_FBW7_1	0.0556
p.A955V	SIDM01611	Endometrial Carcinoma	GDSC	LSTPPNS	DEG_SCF_FBW7_1	0.0556
p.A955V	ACH-000996	Endometrial/Uterine Cancer	CCLE	LSTPPNS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4KMG0	Cell adhesion molecule-related/down-regulated by oncogenes	DEG_SCF_FBW7_1	939:945	LSTPPNS	FBXW7	0.7906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons