DegronMD - Q4KMG0(CDON)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P942H	TCGA-18-3407	LUSC	TCGA	LSTPPNS	DEG_SCF_FBW7_1	939:945	Mutation altering degron motif	0.7694
p.T1098S	TCGA-37-A5EM	LUSC	TCGA	NGGGMYTAVP	CBL_PTK	1092:1101	Mutation altering degron motif	0.6005
p.A1099T	TCGA-AA-3821	COAD	TCGA	NGGGMYTAVP	CBL_PTK	1092:1101	Mutation altering degron motif	0.6028
p.D1104H	TCGA-AC-A23H	BRCA	TCGA	NGGGMYTAVP	CBL_PTK	1092:1101	Mutation rewiring degron network	0.25
p.G947V	TCGA-B5-A11E	UCEC	TCGA	LSTPPNS	DEG_SCF_FBW7_1	939:945	Mutation rewiring degron network	0.2778
p.S945Y	TCGA-BK-A6W3	UCEC	TCGA	LSTPPNS	DEG_SCF_FBW7_1	939:945	Mutation altering degron motif	0.8231
p.S945Y	SIDM00534	Colorectal Carcinoma	GDSC	LSTPPNS	DEG_SCF_FBW7_1	939:945	Mutation altering degron motif	0.8231
p.S945Y	SIDM01611	Endometrial Carcinoma	GDSC	LSTPPNS	DEG_SCF_FBW7_1	939:945	Mutation altering degron motif	0.8231
p.S945Y	ACH-000986	Colon/Colorectal Cancer	CCLE	LSTPPNS	DEG_SCF_FBW7_1	939:945	Mutation altering degron motif	0.8231
p.S945Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	LSTPPNS	DEG_SCF_FBW7_1	939:945	Mutation altering degron motif	0.8231
p.S945Y	HT-115	large intestine	COSMIC	LSTPPNS	DEG_SCF_FBW7_1	939:945	Mutation altering degron motif	0.8231
p.T941A	TCGA-BR-4184	STAD	TCGA	LSTPPNS	DEG_SCF_FBW7_1	939:945	Mutation altering degron motif	0.825
p.H1088L	TCGA-CJ-4904	KIRC	TCGA	NGGGMYTAVP	CBL_PTK	1092:1101	Mutation rewiring degron network	0.2222
p.I1103F	TCGA-CR-7379	HNSC	TCGA	NGGGMYTAVP	CBL_PTK	1092:1101	Mutation rewiring degron network	0.2778
p.E1107K	TCGA-D1-A103	UCEC	TCGA	NGGGMYTAVP	CBL_PTK	1092:1101	Mutation rewiring degron network	0.1667
p.V1100M	TCGA-DF-A2KU	UCEC	TCGA	NGGGMYTAVP	CBL_PTK	1092:1101	Mutation altering degron motif	0.6097
p.Q1102E	TCGA-DK-AA71	BLCA	TCGA	NGGGMYTAVP	CBL_PTK	1092:1101	Mutation rewiring degron network	0.3056
p.D938Y	TCGA-E6-A1LX	UCEC	TCGA	LSTPPNS	DEG_SCF_FBW7_1	939:945	Mutation rewiring degron network	0.3056
p.P943T	TCGA-E8-A2EA	THCA	TCGA	LSTPPNS	DEG_SCF_FBW7_1	939:945	Mutation altering degron motif	0.5919
p.G1093S	TCGA-FD-A3SN	BLCA	TCGA	NGGGMYTAVP	CBL_PTK	1092:1101	Mutation altering degron motif	0.5882
p.H1089N	TCGA-FU-A3HZ	CESC	TCGA	NGGGMYTAVP	CBL_PTK	1092:1101	Mutation rewiring degron network	0.25
p.P1101H	TCGA-GN-A265	SKCM	TCGA	NGGGMYTAVP	CBL_PTK	1092:1101	Mutation altering degron motif	0.7694
p.H1088Y	TCGA-K4-A3WU	BLCA	TCGA	NGGGMYTAVP	CBL_PTK	1092:1101	Mutation rewiring degron network	0.2222
p.A955V	SIDM02015	Colorectal Carcinoma	GDSC	LSTPPNS	DEG_SCF_FBW7_1	939:945	Mutation rewiring degron network	0.0556
p.A955V	SIDM01611	Endometrial Carcinoma	GDSC	LSTPPNS	DEG_SCF_FBW7_1	939:945	Mutation rewiring degron network	0.0556
p.A955V	ACH-000996	Endometrial/Uterine Cancer	CCLE	LSTPPNS	DEG_SCF_FBW7_1	939:945	Mutation rewiring degron network	0.0556
p.H1086Q	ACH-001367	Neuroblastoma	CCLE	NGGGMYTAVP	CBL_PTK	1092:1101	Mutation rewiring degron network	0.1667

Kaplan plot for CDON in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDON

UniProt ID: Q4KMG0

Entrez ID: 50937

Protein name: Cell adhesion molecule-related/down-regulated by oncogenes

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDON in