DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NGGGMYTAVP
Uniprot ID:
Q4KMG0
Source protein:
Cell adhesion molecule-related/down-regulated by oncogenes
Source gene:
CDON
Class:
CBL_PTK
Location:
1092:1101
E3 ligase:
CBL
DEGRON score:
0.9508
ASA_SCORE:
58.49
COIL:
0.7834
CONS_SCORE:
0.5266
DSS_SCORE:
0.2843
HELIX:
0.0361
FCONS_SCORE:
1.0549
RIG_SCORE:
0.7204
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T1098S
TCGA-37-A5EM
LUSC
TCGA
NGGGMYTAVP
CBL_PTK
0.6005
p.A1099T
TCGA-AA-3821
COAD
TCGA
NGGGMYTAVP
CBL_PTK
0.6028
p.D1104H
TCGA-AC-A23H
BRCA
TCGA
NGGGMYTAVP
CBL_PTK
0.25
p.H1088L
TCGA-CJ-4904
KIRC
TCGA
NGGGMYTAVP
CBL_PTK
0.2222
p.I1103F
TCGA-CR-7379
HNSC
TCGA
NGGGMYTAVP
CBL_PTK
0.2778
p.E1107K
TCGA-D1-A103
UCEC
TCGA
NGGGMYTAVP
CBL_PTK
0.1667
p.V1100M
TCGA-DF-A2KU
UCEC
TCGA
NGGGMYTAVP
CBL_PTK
0.6097
p.Q1102E
TCGA-DK-AA71
BLCA
TCGA
NGGGMYTAVP
CBL_PTK
0.3056
p.G1093S
TCGA-FD-A3SN
BLCA
TCGA
NGGGMYTAVP
CBL_PTK
0.5882
p.H1089N
TCGA-FU-A3HZ
CESC
TCGA
NGGGMYTAVP
CBL_PTK
0.25
p.P1101H
TCGA-GN-A265
SKCM
TCGA
NGGGMYTAVP
CBL_PTK
0.7694
p.H1088Y
TCGA-K4-A3WU
BLCA
TCGA
NGGGMYTAVP
CBL_PTK
0.2222
p.H1086Q
ACH-001367
Neuroblastoma
CCLE
NGGGMYTAVP
CBL_PTK
0.1667
Drug responses associated with CDON mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NGGGMYTAVP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q4KMG0
Cell adhesion molecule-related/down-regulated by oncogenes
CBL_PTK
1092:1101
NGGGMYTAVP
CBL
0.9508
More...