DegronMD

Uniprot ID: Q7Z6E9

Source protein: E3 ubiquitin-protein ligase RBBP6

Source gene: RBBP6

Class: DEG_SCF_FBW7_1

Location: 611:617

E3 ligase: FBXW7

DEGRON score: 0.9907

ASA_SCORE: 71.6857

COIL: 0.937

CONS_SCORE: 0.3232

DSS_SCORE: 0.5497

HELIX: 0.0283

FCONS_SCORE: 0.9679

RIG_SCORE: 0.6699

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W615C	TCGA-51-6867	LUSC	TCGA	LSTPWVS	DEG_SCF_FBW7_1	0.5889
p.W615C	DO26477	LUSC	ICGC	LSTPWVS	DEG_SCF_FBW7_1	0.5889
p.P602S	TCGA-D3-A2JF	SKCM	TCGA	LSTPWVS	DEG_SCF_FBW7_1	0.0833
p.P602S	DO38153	SKCM	ICGC	LSTPWVS	DEG_SCF_FBW7_1	0.0833
p.S617L	TCGA-GF-A3OT	SKCM	TCGA	LSTPWVS	DEG_SCF_FBW7_1	0.7667
p.S617L	DO47288	SKCM	ICGC	LSTPWVS	DEG_SCF_FBW7_1	0.7667
p.S617L	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	LSTPWVS	DEG_SCF_FBW7_1	0.7667
p.S617L	ACH-000705	Lung Cancer	CCLE	LSTPWVS	DEG_SCF_FBW7_1	0.7667
p.S617L	ACH-001113	Lung Cancer	CCLE	LSTPWVS	DEG_SCF_FBW7_1	0.7667
p.T613A	TCGA-L5-A4OI	ESCA	TCGA	LSTPWVS	DEG_SCF_FBW7_1	0.7139
p.P605S	TCGA-QB-A6FS	SKCM	TCGA	LSTPWVS	DEG_SCF_FBW7_1	0.1667
p.P605S	DO48654	SKCM	ICGC	LSTPWVS	DEG_SCF_FBW7_1	0.1667
p.A623T	TCGA-SJ-A6ZI	UCEC	TCGA	LSTPWVS	DEG_SCF_FBW7_1	0.1667
p.A623T	DO219784	UCEC	ICGC	LSTPWVS	DEG_SCF_FBW7_1	0.1667
p.L611I	SIDM00845	Burkitt's Lymphoma	GDSC	LSTPWVS	DEG_SCF_FBW7_1	0.6063
p.L611I	SIDM00461	Acute Myeloid Leukemia	GDSC	LSTPWVS	DEG_SCF_FBW7_1	0.6063
p.L611I	SIDM01519	Head and Neck Carcinoma	GDSC	LSTPWVS	DEG_SCF_FBW7_1	0.6063
p.L611I	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LSTPWVS	DEG_SCF_FBW7_1	0.6063
p.G603W	SIDM00143	Small Cell Lung Carcinoma	GDSC	LSTPWVS	DEG_SCF_FBW7_1	0.1111
p.G603W	ACH-000803	Lung Cancer	CCLE	LSTPWVS	DEG_SCF_FBW7_1	0.1111
p.G603W	COLO-668	lung	COSMIC	LSTPWVS	DEG_SCF_FBW7_1	0.1111
p.H624Y	SIDM00240	Cervical Carcinoma	GDSC	LSTPWVS	DEG_SCF_FBW7_1	0.1389
p.H624Y	OMC-1	cervix	COSMIC	LSTPWVS	DEG_SCF_FBW7_1	0.1389
p.R620C	HT-115	large_intestine	COSMIC	LSTPWVS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	DEG_SCF_FBW7_1	611:617	LSTPWVS	FBXW7	0.9907	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons