DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 295:302

E3 ligase: FBXW7

DEGRON score: 0.8325

ASA_SCORE: 84.6

COIL: 0.822

CONS_SCORE: 0.5236

DSS_SCORE: 0.4348

HELIX: 0.0148

FCONS_SCORE: 0.8797

RIG_SCORE: 0.7196

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P299S	TCGA-3N-A9WC	SKCM	TCGA	LSTTPAAT	DEG_SCF_FBW7_1	0.6752
p.P299S	DO222494	MELA	ICGC	LSTTPAAT	DEG_SCF_FBW7_1	0.6752
p.P299S	DO51234	SKCM	ICGC	LSTTPAAT	DEG_SCF_FBW7_1	0.6752
p.A300V	TCGA-A5-A0G1	UCEC	TCGA	LSTTPAAT	DEG_SCF_FBW7_1	0.5825
p.A300V	DO42472	UCEC	ICGC	LSTTPAAT	DEG_SCF_FBW7_1	0.5825
p.I304F	TCGA-D9-A6EC	SKCM	TCGA	LSTTPAAT	DEG_SCF_FBW7_1	0.2778
p.I304F	DO50291	SKCM	ICGC	LSTTPAAT	DEG_SCF_FBW7_1	0.2778
p.N303S	TCGA-EM-A2P0	THCA	TCGA	LSTTPAAT	DEG_SCF_FBW7_1	0.3056
p.N303S	DO39622	THCA	ICGC	LSTTPAAT	DEG_SCF_FBW7_1	0.3056
p.T302A	TCGA-FI-A2F4	UCEC	TCGA	LSTTPAAT	DEG_SCF_FBW7_1	0.7139
p.T302A	DO43434	UCEC	ICGC	LSTTPAAT	DEG_SCF_FBW7_1	0.7139
p.A312T	DO228483	BRCA	ICGC	LSTTPAAT	DEG_SCF_FBW7_1	0.0556
p.V288A	DO229057	LICA	ICGC	LSTTPAAT	DEG_SCF_FBW7_1	0.1389
p.P305L	DO231909	LINC	ICGC	LSTTPAAT	DEG_SCF_FBW7_1	0.25
p.L295F	DO220886	MELA	ICGC	LSTTPAAT	DEG_SCF_FBW7_1	0.6981
p.A300T	SIDM00578	Neuroblastoma	GDSC	LSTTPAAT	DEG_SCF_FBW7_1	0.6028
p.A300T	ACH-000804	Neuroblastoma	CCLE	LSTTPAAT	DEG_SCF_FBW7_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	295:302	LSTTPAAT	FBXW7	0.8325	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons