DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 1534:1541

E3 ligase: FBXW7

DEGRON score: 0.5715

ASA_SCORE: 90.9375

COIL: 0.8406

CONS_SCORE: 0.5236

DSS_SCORE: 0.4553

HELIX: 0.0126

FCONS_SCORE: 0.9966

RIG_SCORE: 0.7083

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1528T	TCGA-61-1738	OV	TCGA	LSTTPAVT	DEG_SCF_FBW7_1	0.1667
p.S1528T	DO30380	OV	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.1667
p.T1546I	TCGA-AX-A1CE	UCEC	TCGA	LSTTPAVT	DEG_SCF_FBW7_1	0.1944
p.T1546I	DO42280	UCEC	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.1944
p.T1536A	TCGA-AY-4070	COAD	TCGA	LSTTPAVT	DEG_SCF_FBW7_1	0.6028
p.T1536A	DO10518	COAD	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.6028
p.P1538L	TCGA-BR-4253	STAD	TCGA	LSTTPAVT	DEG_SCF_FBW7_1	0.7582
p.P1538L	DO38455	STAD	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.7582
p.S1549Y	TCGA-BS-A0UV	UCEC	TCGA	LSTTPAVT	DEG_SCF_FBW7_1	0.1111
p.S1549Y	DO42793	UCEC	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.1111
p.T1541N	TCGA-CV-A45W	HNSC	TCGA	LSTTPAVT	DEG_SCF_FBW7_1	0.7055
p.T1541N	DO52060	HNSC	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.7055
p.L1534F	TCGA-D3-A8GC	SKCM	TCGA	LSTTPAVT	DEG_SCF_FBW7_1	0.6981
p.L1534F	DO50281	SKCM	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.6981
p.P1538A	TCGA-DU-7007	LGG	TCGA	LSTTPAVT	DEG_SCF_FBW7_1	0.7503
p.P1538A	DO22400	LGG	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.7503
p.T1524S	TCGA-NC-A5HJ	LUSC	TCGA	LSTTPAVT	DEG_SCF_FBW7_1	0.0556
p.T1524S	DO219189	LUSC	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.0556
p.S1549P	DO224726	COCA	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.1111
p.S1549P	DO224731	COCA	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.1111
p.T1541P	DO224731	COCA	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.7031
p.T1541P	DO224754	COCA	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.7031
p.T1541P	DO222718	COCA	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.7031
p.T1541P	DO228390	LICA	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.7031
p.T1541P	DO228531	LICA	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.7031
p.T1541P	DO52361	LUSC	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.7031
p.T1541P	DO52357	LUSC	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.7031
p.V1540D	DO222718	COCA	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.6674
p.V1540D	DO228390	LICA	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.6674
p.V1540D	DO228531	LICA	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.6674
p.V1540D	DO228950	LICA	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.6674
p.V1540D	DO228967	LICA	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.6674
p.V1540D	DO229030	LICA	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.6674
p.V1540D	DO229057	LICA	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.6674
p.V1540D	DO52361	LUSC	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.6674
p.V1540D	DO52357	LUSC	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.6674
p.E1530K	DO222749	MELA	ICGC	LSTTPAVT	DEG_SCF_FBW7_1	0.2222
p.P1544T	SIDM00656	Burkitt's Lymphoma	GDSC	LSTTPAVT	DEG_SCF_FBW7_1	0.25
p.P1544T	ACH-000944	Lymphoma	CCLE	LSTTPAVT	DEG_SCF_FBW7_1	0.25
p.P1544T	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	LSTTPAVT	DEG_SCF_FBW7_1	0.25
p.A1551T	SIDM00669	Pancreatic Carcinoma	GDSC	LSTTPAVT	DEG_SCF_FBW7_1	0.0556
p.A1551T	HPAF-II	pancreas	COSMIC	LSTTPAVT	DEG_SCF_FBW7_1	0.0556
p.P1544H	SIDM00274	Gastric Carcinoma	GDSC	LSTTPAVT	DEG_SCF_FBW7_1	0.25
p.P1544H	ACH-000047	Gastric Cancer	CCLE	LSTTPAVT	DEG_SCF_FBW7_1	0.25
p.P1544H	GCIY	stomach	COSMIC	LSTTPAVT	DEG_SCF_FBW7_1	0.25
p.S1529Y	SIDM00975	Melanoma	GDSC	LSTTPAVT	DEG_SCF_FBW7_1	0.1944
p.S1529Y	ACH-002206	Skin Cancer	CCLE	LSTTPAVT	DEG_SCF_FBW7_1	0.1944
p.S1529Y	WM278	skin	COSMIC	LSTTPAVT	DEG_SCF_FBW7_1	0.1944
p.A1551V	SW982	soft_tissue	COSMIC	LSTTPAVT	DEG_SCF_FBW7_1	0.0556
p.S1549A	SW982	soft_tissue	COSMIC	LSTTPAVT	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSTTPAVT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of LSTTPAVT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	1534:1541	LSTTPAVT	FBXW7	0.5715	More...