DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 1593:1600

E3 ligase: FBXW7

DEGRON score: 0.7929

ASA_SCORE: 90.3125

COIL: 0.8836

CONS_SCORE: 0.5236

DSS_SCORE: 0.5006

HELIX: 0.0183

FCONS_SCORE: 0.8738

RIG_SCORE: 0.7381

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1603E	TCGA-34-5231	LUSC	TCGA	LSTTPIDS	DEG_SCF_FBW7_1	0.25
p.Q1603E	DO26772	LUSC	ICGC	LSTTPIDS	DEG_SCF_FBW7_1	0.25
p.A1590T	TCGA-55-A4DG	LUAD	TCGA	LSTTPIDS	DEG_SCF_FBW7_1	0.25
p.A1590T	DO26337	LUAD	ICGC	LSTTPIDS	DEG_SCF_FBW7_1	0.25
p.S1600Y	TCGA-77-A5G8	LUSC	TCGA	LSTTPIDS	DEG_SCF_FBW7_1	0.712
p.S1600Y	DO50099	LUSC	ICGC	LSTTPIDS	DEG_SCF_FBW7_1	0.712
p.A1590D	TCGA-BJ-A2P4	THCA	TCGA	LSTTPIDS	DEG_SCF_FBW7_1	0.25
p.A1590D	DO49750	THCA	ICGC	LSTTPIDS	DEG_SCF_FBW7_1	0.25
p.E1589D	TCGA-BT-A2LD	BLCA	TCGA	LSTTPIDS	DEG_SCF_FBW7_1	0.2222
p.E1589D	DO578	BLCA	ICGC	LSTTPIDS	DEG_SCF_FBW7_1	0.2222
p.A1606T	TCGA-EO-A22U	UCEC	TCGA	LSTTPIDS	DEG_SCF_FBW7_1	0.1667
p.A1606T	DO43755	UCEC	ICGC	LSTTPIDS	DEG_SCF_FBW7_1	0.1667
p.L1593F	TCGA-ER-A2NC	SKCM	TCGA	LSTTPIDS	DEG_SCF_FBW7_1	0.6981
p.L1593F	DO47318	SKCM	ICGC	LSTTPIDS	DEG_SCF_FBW7_1	0.6981
p.E1589Q	TCGA-LP-A5U2	CESC	TCGA	LSTTPIDS	DEG_SCF_FBW7_1	0.2222
p.E1589Q	DO51610	CESC	ICGC	LSTTPIDS	DEG_SCF_FBW7_1	0.2222
p.T1596I	DO222880	MELA	ICGC	LSTTPIDS	DEG_SCF_FBW7_1	0.7078
p.M1583R	SIDM01199	Hepatocellular Carcinoma	GDSC	LSTTPIDS	DEG_SCF_FBW7_1	0.0556
p.M1583R	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	LSTTPIDS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	1593:1600	LSTTPIDS	FBXW7	0.7929	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons