DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
LSTTPKVS
Uniprot ID:
Q8NDM7
Source protein:
Cilia- and flagella-associated protein 43
Source gene:
CFAP43
Class:
DEG_SCF_FBW7_1
Location:
746:753
E3 ligase:
FBXW7
DEGRON score:
0.9933
ASA_SCORE:
69.6625
COIL:
0.6803
CONS_SCORE:
0.2892
DSS_SCORE:
0.4286
HELIX:
0.1923
FCONS_SCORE:
1.1948
RIG_SCORE:
0.7235
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D740N
SIDM00527
Colorectal Carcinoma
GDSC
LSTTPKVS
DEG_SCF_FBW7_1
0.1667
p.D740N
MDST8
large_intestine
COSMIC
LSTTPKVS
DEG_SCF_FBW7_1
0.1667
Drug responses associated with CFAP43 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LSTTPKVS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NDM7
Cilia- and flagella-associated protein 43
DEG_SCF_FBW7_1
746:753
LSTTPKVS
FBXW7
0.9933
More...