DegronMD - Q8NDM7(CFAP43)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1337Y	SIDM00608	Plasma Cell Myeloma	GDSC	VVPFGE	LIG_APCC_ABBA_1	1328:1333	Mutation rewiring degron network	0.2222
p.S1337Y	KMS-11	haematopoietic and lymphoid tissue	COSMIC	VVPFGE	LIG_APCC_ABBA_1	1328:1333	Mutation rewiring degron network	0.2222
p.V1328I	SIDM00680	Colorectal Carcinoma	GDSC	VVPFGE	LIG_APCC_ABBA_1	1328:1333	Mutation altering degron motif	0.5965
p.V1328I	SIDM01664	Prostate Carcinoma	GDSC	VVPFGE	LIG_APCC_ABBA_1	1328:1333	Mutation altering degron motif	0.5965
p.V1328I	LS-180	large intestine	COSMIC	VVPFGE	LIG_APCC_ABBA_1	1328:1333	Mutation altering degron motif	0.5965
p.T1321A	SIDM00238	Ovarian Carcinoma	GDSC	VVPFGE	LIG_APCC_ABBA_1	1328:1333	Mutation rewiring degron network	0.1389
p.T1321A	OVK-18	ovary	COSMIC	VVPFGE	LIG_APCC_ABBA_1	1328:1333	Mutation rewiring degron network	0.1389
p.D740N	SIDM00527	Colorectal Carcinoma	GDSC	LSTTPKVS	DEG_SCF_FBW7_1	746:753	Mutation rewiring degron network	0.1667
p.D740N	MDST8	large intestine	COSMIC	LSTTPKVS	DEG_SCF_FBW7_1	746:753	Mutation rewiring degron network	0.1667
p.S1337P	SIDM00930	Osteosarcoma	GDSC	VVPFGE	LIG_APCC_ABBA_1	1328:1333	Mutation rewiring degron network	0.2222
p.S1337P	CAL-72	bone	COSMIC	VVPFGE	LIG_APCC_ABBA_1	1328:1333	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons