DegronMD

Uniprot ID: Q8NDM7

Source protein: Cilia- and flagella-associated protein 43

Source gene: CFAP43

Class: LIG_APCC_ABBA_1

Location: 1328:1333

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9994

ASA_SCORE: 79.85

COIL: 0.7903

CONS_SCORE: 0.3716

DSS_SCORE: 0.4868

HELIX: 0.077

FCONS_SCORE: 1.3156

RIG_SCORE: 0.7266

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1337Y	SIDM00608	Plasma Cell Myeloma	GDSC	VVPFGE	LIG_APCC_ABBA_1	0.2222
p.S1337Y	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	VVPFGE	LIG_APCC_ABBA_1	0.2222
p.V1328I	SIDM00680	Colorectal Carcinoma	GDSC	VVPFGE	LIG_APCC_ABBA_1	0.5965
p.V1328I	SIDM01664	Prostate Carcinoma	GDSC	VVPFGE	LIG_APCC_ABBA_1	0.5965
p.V1328I	LS-180	large_intestine	COSMIC	VVPFGE	LIG_APCC_ABBA_1	0.5965
p.T1321A	SIDM00238	Ovarian Carcinoma	GDSC	VVPFGE	LIG_APCC_ABBA_1	0.1389
p.T1321A	OVK-18	ovary	COSMIC	VVPFGE	LIG_APCC_ABBA_1	0.1389
p.S1337P	SIDM00930	Osteosarcoma	GDSC	VVPFGE	LIG_APCC_ABBA_1	0.2222
p.S1337P	CAL-72	bone	COSMIC	VVPFGE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NDM7	Cilia- and flagella-associated protein 43	LIG_APCC_ABBA_1	1328:1333	VVPFGE	APC,CDC20,FZR1	0.9994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons