DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 2109:2116

E3 ligase: FBXW7

DEGRON score: 0.6765

ASA_SCORE: 86.9125

COIL: 0.9243

CONS_SCORE: 0.5536

DSS_SCORE: 0.5388

HELIX: 0.0113

FCONS_SCORE: 0.9055

RIG_SCORE: 0.6756

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2118G	TCGA-20-1686	OV	TCGA	LSTTPVAS	DEG_SCF_FBW7_1	0.2778
p.E2118G	DO31380	OV	ICGC	LSTTPVAS	DEG_SCF_FBW7_1	0.2778
p.T2112M	TCGA-4Z-AA7S	BLCA	TCGA	LSTTPVAS	DEG_SCF_FBW7_1	0.7423
p.T2112M	TCGA-HT-A74H	LGG	TCGA	LSTTPVAS	DEG_SCF_FBW7_1	0.7423
p.T2112M	DO218982	BLCA	ICGC	LSTTPVAS	DEG_SCF_FBW7_1	0.7423
p.T2112M	DO219815	LGG	ICGC	LSTTPVAS	DEG_SCF_FBW7_1	0.7423
p.T2112M	NCI-H1836	lung	COSMIC	LSTTPVAS	DEG_SCF_FBW7_1	0.7423
p.A2115S	TCGA-75-6214	LUAD	TCGA	LSTTPVAS	DEG_SCF_FBW7_1	0.6477
p.A2115S	DO24830	LUAD	ICGC	LSTTPVAS	DEG_SCF_FBW7_1	0.6477
p.G2100E	TCGA-D3-A8GM	SKCM	TCGA	LSTTPVAS	DEG_SCF_FBW7_1	0.0833
p.G2100E	DO50288	SKCM	ICGC	LSTTPVAS	DEG_SCF_FBW7_1	0.0833
p.S2101N	TCGA-D6-6516	HNSC	TCGA	LSTTPVAS	DEG_SCF_FBW7_1	0.1111
p.S2101N	DO15623	HNSC	ICGC	LSTTPVAS	DEG_SCF_FBW7_1	0.1111
p.L2122F	TCGA-D9-A6EA	SKCM	TCGA	LSTTPVAS	DEG_SCF_FBW7_1	0.1667
p.L2122F	DO50290	SKCM	ICGC	LSTTPVAS	DEG_SCF_FBW7_1	0.1667
p.S2116I	TCGA-DX-AB2O	SARC	TCGA	LSTTPVAS	DEG_SCF_FBW7_1	0.7341
p.S2116I	DO220083	SARC	ICGC	LSTTPVAS	DEG_SCF_FBW7_1	0.7341
p.S2110I	TCGA-EE-A3JD	SKCM	TCGA	LSTTPVAS	DEG_SCF_FBW7_1	0.623
p.S2110I	DO50299	SKCM	ICGC	LSTTPVAS	DEG_SCF_FBW7_1	0.623
p.S2110R	TCGA-EE-A3JD	SKCM	TCGA	LSTTPVAS	DEG_SCF_FBW7_1	0.6316
p.S2110R	TCGA-L9-A743	LUAD	TCGA	LSTTPVAS	DEG_SCF_FBW7_1	0.6316
p.S2110R	DO49874	LUAD	ICGC	LSTTPVAS	DEG_SCF_FBW7_1	0.6316
p.S2110R	DO50299	SKCM	ICGC	LSTTPVAS	DEG_SCF_FBW7_1	0.6316
p.L2103V	TCGA-FD-A5C1	BLCA	TCGA	LSTTPVAS	DEG_SCF_FBW7_1	0.1667
p.L2103V	DO44043	BLCA	ICGC	LSTTPVAS	DEG_SCF_FBW7_1	0.1667
p.P2113S	TCGA-FS-A1ZZ	SKCM	TCGA	LSTTPVAS	DEG_SCF_FBW7_1	0.6752
p.P2113S	DO37412	SKCM	ICGC	LSTTPVAS	DEG_SCF_FBW7_1	0.6752
p.S2106R	TCGA-HU-A4GH	STAD	TCGA	LSTTPVAS	DEG_SCF_FBW7_1	0.25
p.S2106R	DO47743	STAD	ICGC	LSTTPVAS	DEG_SCF_FBW7_1	0.25
p.A2115D	TCGA-LN-A5U6	ESCA	TCGA	LSTTPVAS	DEG_SCF_FBW7_1	0.6682
p.P2126A	TCGA-VS-A9UH	CESC	TCGA	LSTTPVAS	DEG_SCF_FBW7_1	0.0556
p.P2126A	DO51642	CESC	ICGC	LSTTPVAS	DEG_SCF_FBW7_1	0.0556
p.L2109V	DO229376	BTCA	ICGC	LSTTPVAS	DEG_SCF_FBW7_1	0.5654
p.P2117S	DO228960	LICA	ICGC	LSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.T2124A	DO229060	LICA	ICGC	LSTTPVAS	DEG_SCF_FBW7_1	0.1111
p.A2119S	DO229009	LICA	ICGC	LSTTPVAS	DEG_SCF_FBW7_1	0.25
p.T2105A	DO51576	LUSC	ICGC	LSTTPVAS	DEG_SCF_FBW7_1	0.2222
p.E2118V	DO230530	LUSC	ICGC	LSTTPVAS	DEG_SCF_FBW7_1	0.2778
p.P2102L	DO220907	MELA	ICGC	LSTTPVAS	DEG_SCF_FBW7_1	0.1389
p.P2113L	SIDM01308	Esophageal Carcinoma	GDSC	LSTTPVAS	DEG_SCF_FBW7_1	0.7582
p.P2113L	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	LSTTPVAS	DEG_SCF_FBW7_1	0.7582
p.P2113L	LCLC-97TM1	lung	COSMIC	LSTTPVAS	DEG_SCF_FBW7_1	0.7582
p.P2117L	SIDM00321	Ovarian Carcinoma	GDSC	LSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.P2117L	SIDM00315	Glioblastoma	GDSC	LSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.P2117L	SIDM00296	Small Cell Lung Carcinoma	GDSC	LSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.P2117L	SIDM00360	Other Solid Cancers	GDSC	LSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.P2117L	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	LSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.P2117L	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	LSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.P2117L	SIDM00380	Acute Myeloid Leukemia	GDSC	LSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.P2117L	SIDM00877	Breast Carcinoma	GDSC	LSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.P2117L	SIDM01335	Kidney Carcinoma	GDSC	LSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.P2117L	SIDM01526	Mesothelioma	GDSC	LSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.P2117L	TYK-nu	ovary	COSMIC	LSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.P2117L	QGP-1	pancreas	COSMIC	LSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.P2117L	YKG-1	central_nervous_system	COSMIC	LSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.P2117L	TE-15	oesophagus	COSMIC	LSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.P2117L	HCC1599	breast	COSMIC	LSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.P2117L	KYSE-450	oesophagus	COSMIC	LSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.P2117L	LU-134-A	lung	COSMIC	LSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.P2117L	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	LSTTPVAS	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSTTPVAS

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of LSTTPVAS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	2109:2116	LSTTPVAS	FBXW7	0.6765	More...