DegronMD

Uniprot ID: O76041

Source protein: Nebulette

Source gene: NEBL

Class: DEG_SCF_FBW7_2

Location: 729:736

E3 ligase: FBXW7

DEGRON score: 0.9884

ASA_SCORE: 69.9625

COIL: 0.505

CONS_SCORE: 0.65

DSS_SCORE: 0.5277

HELIX: 0.4653

FCONS_SCORE: 1.3484

RIG_SCORE: 0.769

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P733L	DO222868	MELA	ICGC	LSVTPEME	DEG_SCF_FBW7_2	0.7582
p.M735I	DO234412	ESAD	ICGC	LSVTPEME	DEG_SCF_FBW7_2	0.6507
p.S730R	TCGA-CG-4466	STAD	TCGA	LSVTPEME	DEG_SCF_FBW7_2	0.6316
p.S730R	DO38695	STAD	ICGC	LSVTPEME	DEG_SCF_FBW7_2	0.6316
p.S730R	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.6316
p.S730R	ACH-002307	Lymphoma	CCLE	LSVTPEME	DEG_SCF_FBW7_2	0.6316
p.S730R	SU-DHL-16	haematopoietic_and_lymphoid_tissue	COSMIC	LSVTPEME	DEG_SCF_FBW7_2	0.6316
p.S730N	DO229363	BTCA	ICGC	LSVTPEME	DEG_SCF_FBW7_2	0.5958
p.V731L	DO45151	LIRI	ICGC	LSVTPEME	DEG_SCF_FBW7_2	0.5654
p.K740Q	TCGA-A5-A0G2	UCEC	TCGA	LSVTPEME	DEG_SCF_FBW7_2	0.3333
p.K740Q	DO41235	UCEC	ICGC	LSVTPEME	DEG_SCF_FBW7_2	0.3333
p.T728A	DO52365	LUSC	ICGC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM01034	B-Lymphoblastic Leukemia	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00435	Acute Myeloid Leukemia	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00586	Hepatocellular Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00557	Neuroblastoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00588	Oral Cavity Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM01004	Chronic Myelogenous Leukemia	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00215	Colorectal Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00232	Kidney Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00572	Gastric Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00584	Osteosarcoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00602	Gastric Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00544	Neuroblastoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056

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Drug responses associated with NEBL mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of LSVTPEME

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O76041	Nebulette	DEG_SCF_FBW7_2	729:736	LSVTPEME	FBXW7	0.9884	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSVTPEME

Degron related mutations and impact score

Drug responses associated with NEBL mutations

All proteins holding degron of LSVTPEME