DegronMD

Uniprot ID: O76041

Source protein: Nebulette

Source gene: NEBL

Class: DEG_SCF_FBW7_2

Location: 729:736

E3 ligase: FBXW7

DEGRON score: 0.9884

ASA_SCORE: 69.9625

COIL: 0.505

CONS_SCORE: 0.65

DSS_SCORE: 0.5277

HELIX: 0.4653

FCONS_SCORE: 1.3484

RIG_SCORE: 0.769

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K740Q	TCGA-A5-A0G2	UCEC	TCGA	LSVTPEME	DEG_SCF_FBW7_2	0.3333
p.K740Q	DO41235	UCEC	ICGC	LSVTPEME	DEG_SCF_FBW7_2	0.3333
p.R720I	TCGA-AP-A0LM	UCEC	TCGA	LSVTPEME	DEG_SCF_FBW7_2	0.0833
p.R720I	DO43306	UCEC	ICGC	LSVTPEME	DEG_SCF_FBW7_2	0.0833
p.S730R	TCGA-CG-4466	STAD	TCGA	LSVTPEME	DEG_SCF_FBW7_2	0.6316
p.S730R	DO38695	STAD	ICGC	LSVTPEME	DEG_SCF_FBW7_2	0.6316
p.S730R	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.6316
p.S730R	ACH-002307	Lymphoma	CCLE	LSVTPEME	DEG_SCF_FBW7_2	0.6316
p.S730R	SU-DHL-16	haematopoietic_and_lymphoid_tissue	COSMIC	LSVTPEME	DEG_SCF_FBW7_2	0.6316
p.A726T	TCGA-D9-A6EC	SKCM	TCGA	LSVTPEME	DEG_SCF_FBW7_2	0.25
p.A726T	DO50291	SKCM	ICGC	LSVTPEME	DEG_SCF_FBW7_2	0.25
p.L723M	TCGA-FD-A6TH	BLCA	TCGA	LSVTPEME	DEG_SCF_FBW7_2	0.1667
p.L723M	DO49763	BLCA	ICGC	LSVTPEME	DEG_SCF_FBW7_2	0.1667
p.E743K	TCGA-WE-A8K1	SKCM	TCGA	LSVTPEME	DEG_SCF_FBW7_2	0.1389
p.E743K	DO51280	SKCM	ICGC	LSVTPEME	DEG_SCF_FBW7_2	0.1389
p.S730N	DO229363	BTCA	ICGC	LSVTPEME	DEG_SCF_FBW7_2	0.5958
p.M735I	DO234412	ESAD	ICGC	LSVTPEME	DEG_SCF_FBW7_2	0.6507
p.V731L	DO45151	LIRI	ICGC	LSVTPEME	DEG_SCF_FBW7_2	0.5654
p.T728A	DO52365	LUSC	ICGC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM01034	B-Lymphoblastic Leukemia	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00435	Acute Myeloid Leukemia	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00586	Hepatocellular Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00557	Neuroblastoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00588	Oral Cavity Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM01004	Chronic Myelogenous Leukemia	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00215	Colorectal Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00232	Kidney Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00572	Gastric Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00584	Osteosarcoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00602	Gastric Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00544	Neuroblastoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00890	Melanoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00592	Oral Cavity Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00492	Glioblastoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00351	Oral Cavity Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM01045	Endometrial Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM01146	Gastric Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00907	Burkitt's Lymphoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00576	Acute Myeloid Leukemia	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00280	Gastric Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00469	Pancreatic Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00368	Small Cell Lung Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00560	Gastric Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00363	Acute Myeloid Leukemia	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00850	Gastric Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00316	Glioblastoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00302	Other Solid Cancers	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM01018	Hodgkin's Lymphoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM01695	Acute Myeloid Leukemia	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM01659	Kidney Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM01377	Ovarian Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM01779	Gastric Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM01347	Ovarian Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00161	Biliary Tract Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00163	Biliary Tract Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM01435	Hepatocellular Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM01575	Plasma Cell Myeloma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM01446	Glioblastoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM01690	Plasma Cell Myeloma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM00959	Acute Myeloid Leukemia	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.T728A	SIDM01391	Neuroblastoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.3056
p.P733L	DO222868	MELA	ICGC	LSVTPEME	DEG_SCF_FBW7_2	0.7582
p.S746R	DO46372	OV	ICGC	LSVTPEME	DEG_SCF_FBW7_2	0.0556
p.R720K	SIDM01042	Breast Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.0833
p.S746T	SIDM01138	Pancreatic Carcinoma	GDSC	LSVTPEME	DEG_SCF_FBW7_2	0.0556
p.S746T	ACH-000139	Pancreatic Cancer	CCLE	LSVTPEME	DEG_SCF_FBW7_2	0.0556
p.S746T	PANC-03-27	pancreas	COSMIC	LSVTPEME	DEG_SCF_FBW7_2	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSVTPEME

Degron related mutations and impact score

Drug responses associated with NEBL mutations

All proteins holding degron of LSVTPEME

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O76041	Nebulette	DEG_SCF_FBW7_2	729:736	LSVTPEME	FBXW7	0.9884	More...