DegronMD

Uniprot ID: Q16819

Source protein: Meprin A subunit alpha

Source gene: MEP1A

Class: DEG_SCF_FBW7_1

Location: 426:433

E3 ligase: FBXW7

DEGRON score: 0.7078

ASA_SCORE: 63.7125

COIL: 0.8218

CONS_SCORE: 0.3581

DSS_SCORE: 0.2726

HELIX: 0.0134

FCONS_SCORE: 1.0228

RIG_SCORE: 0.812

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R439L	TCGA-50-6590	LUAD	TCGA	LTETPCPT	DEG_SCF_FBW7_1	0.1667
p.R439L	DO24692	LUAD	ICGC	LTETPCPT	DEG_SCF_FBW7_1	0.1667
p.F441V	TCGA-B5-A1MR	UCEC	TCGA	LTETPCPT	DEG_SCF_FBW7_1	0.1111
p.F441V	DO41758	UCEC	ICGC	LTETPCPT	DEG_SCF_FBW7_1	0.1111
p.R439Q	TCGA-CN-4727	HNSC	TCGA	LTETPCPT	DEG_SCF_FBW7_1	0.1667
p.R439Q	DO225349	BRCA	ICGC	LTETPCPT	DEG_SCF_FBW7_1	0.1667
p.R439Q	DO14258	HNSC	ICGC	LTETPCPT	DEG_SCF_FBW7_1	0.1667
p.R439Q	SIDM00266	Ewing's Sarcoma	GDSC	LTETPCPT	DEG_SCF_FBW7_1	0.1667
p.R439Q	ACH-002103	Bone Cancer	CCLE	LTETPCPT	DEG_SCF_FBW7_1	0.1667
p.R439Q	ES1	bone	COSMIC	LTETPCPT	DEG_SCF_FBW7_1	0.1667
p.E428D	TCGA-E6-A1LX	UCEC	TCGA	LTETPCPT	DEG_SCF_FBW7_1	0.5647
p.E428D	DO41020	UCEC	ICGC	LTETPCPT	DEG_SCF_FBW7_1	0.5647
p.P430S	TCGA-EE-A2MQ	SKCM	TCGA	LTETPCPT	DEG_SCF_FBW7_1	0.6752
p.P430S	DO219878	SKCA	ICGC	LTETPCPT	DEG_SCF_FBW7_1	0.6752
p.P430S	DO37810	SKCM	ICGC	LTETPCPT	DEG_SCF_FBW7_1	0.6752
p.G418E	TCGA-FS-A1ZD	SKCM	TCGA	LTETPCPT	DEG_SCF_FBW7_1	0.1111
p.G418E	DO37627	SKCM	ICGC	LTETPCPT	DEG_SCF_FBW7_1	0.1111
p.R439W	TCGA-GN-A26A	SKCM	TCGA	LTETPCPT	DEG_SCF_FBW7_1	0.1667
p.R439W	DO37861	SKCM	ICGC	LTETPCPT	DEG_SCF_FBW7_1	0.1667
p.D423N	DO48366	BLCA	ICGC	LTETPCPT	DEG_SCF_FBW7_1	0.25
p.T437I	DO234230	ESAD	ICGC	LTETPCPT	DEG_SCF_FBW7_1	0.2222
p.Y420F	DO222418	MELA	ICGC	LTETPCPT	DEG_SCF_FBW7_1	0.1667
p.G434W	SIDM01943	Colorectal Carcinoma	GDSC	LTETPCPT	DEG_SCF_FBW7_1	0.3056
p.Y420N	SIDM00292	Small Cell Lung Carcinoma	GDSC	LTETPCPT	DEG_SCF_FBW7_1	0.1667
p.Y420N	ACH-002077	Lung Cancer	CCLE	LTETPCPT	DEG_SCF_FBW7_1	0.1667
p.Y420N	LU-165	lung	COSMIC	LTETPCPT	DEG_SCF_FBW7_1	0.1667
p.P432L	SIDM00511	Small Cell Lung Carcinoma	GDSC	LTETPCPT	DEG_SCF_FBW7_1	0.6471
p.P432L	ACH-000257	Lung Cancer	CCLE	LTETPCPT	DEG_SCF_FBW7_1	0.6471
p.P432L	COR-L279	lung	COSMIC	LTETPCPT	DEG_SCF_FBW7_1	0.6471
p.F441L	SIDM00837	Colorectal Carcinoma	GDSC	LTETPCPT	DEG_SCF_FBW7_1	0.1111
p.F441L	ACH-000455	Brain Cancer	CCLE	LTETPCPT	DEG_SCF_FBW7_1	0.1111
p.F441L	ACH-000958	Colon/Colorectal Cancer	CCLE	LTETPCPT	DEG_SCF_FBW7_1	0.1111
p.F441L	SW48	large_intestine	COSMIC	LTETPCPT	DEG_SCF_FBW7_1	0.1111
p.P430R	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTETPCPT	DEG_SCF_FBW7_1	0.7512
p.P430R	ACH-001638	Lymphoma	CCLE	LTETPCPT	DEG_SCF_FBW7_1	0.7512
p.P430R	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	LTETPCPT	DEG_SCF_FBW7_1	0.7512
p.I419N	SIDM01608	Endometrial Carcinoma	GDSC	LTETPCPT	DEG_SCF_FBW7_1	0.1389
p.I419N	ACH-000990	Endometrial/Uterine Cancer	CCLE	LTETPCPT	DEG_SCF_FBW7_1	0.1389
p.K417E	EN	endometrium	COSMIC	LTETPCPT	DEG_SCF_FBW7_1	0.0833
p.D439N	NCI-H1770	lung	COSMIC	LTETPCPT	DEG_SCF_FBW7_1	0.1667
p.R430H	SNU-C5	large_intestine	COSMIC	LTETPCPT	DEG_SCF_FBW7_1	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTETPCPT

Degron related mutations and impact score

Drug responses associated with MEP1A mutations

All proteins holding degron of LTETPCPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16819	Meprin A subunit alpha	DEG_SCF_FBW7_1	426:433	LTETPCPT	FBXW7	0.7078	More...