DegronMD - Q16819(MEP1A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R439L	TCGA-50-6590	LUAD	TCGA	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1667
p.R439L	DO24692	LUAD	ICGC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1667
p.A537V	TCGA-B5-A11E	UCEC	TCGA	VFTTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.1389
p.A537V	DO41644	UCEC	ICGC	VFTTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.1389
p.F441V	TCGA-B5-A1MR	UCEC	TCGA	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1111
p.F441V	DO41758	UCEC	ICGC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1111
p.M521V	TCGA-B5-A1MX	UCEC	TCGA	VFTTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.1944
p.M521V	DO41999	UCEC	ICGC	VFTTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.1944
p.S530L	TCGA-CG-4437	STAD	TCGA	VFTTS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.8778
p.S530L	DO38467	STAD	ICGC	VFTTS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.8778
p.R439Q	TCGA-CN-4727	HNSC	TCGA	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1667
p.R439Q	DO225349	BRCA	ICGC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1667
p.R439Q	DO14258	HNSC	ICGC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1667
p.R439Q	SIDM00266	Ewing's Sarcoma	GDSC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1667
p.R439Q	ACH-002103	Bone Cancer	CCLE	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1667
p.R439Q	ES1	bone	COSMIC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1667
p.M525I	TCGA-DA-A1I0	SKCM	TCGA	VFTTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.3056
p.M525I	DO37719	SKCM	ICGC	VFTTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.3056
p.M525I	ACH-002463	Non-Cancerous	CCLE	VFTTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.3056
p.E428D	TCGA-E6-A1LX	UCEC	TCGA	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation altering degron motif	0.5647
p.E428D	DO41020	UCEC	ICGC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation altering degron motif	0.5647
p.P430S	TCGA-EE-A2MQ	SKCM	TCGA	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation altering degron motif	0.6752
p.P430S	DO219878	SKCA	ICGC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation altering degron motif	0.6752
p.P430S	DO37810	SKCM	ICGC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation altering degron motif	0.6752
p.G418E	TCGA-FS-A1ZD	SKCM	TCGA	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1111
p.G418E	DO37627	SKCM	ICGC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1111
p.R439W	TCGA-GN-A26A	SKCM	TCGA	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1667
p.R439W	DO37861	SKCM	ICGC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1667
p.T534A	TCGA-HJ-7597	STAD	TCGA	VFTTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2222
p.T534A	DO222517	BTCA	ICGC	VFTTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2222
p.T534A	DO38195	STAD	ICGC	VFTTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2222
p.F527L	TCGA-L9-A444	LUAD	TCGA	VFTTS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.587
p.F527L	DO26015	LUAD	ICGC	VFTTS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.587
p.R520K	TCGA-YD-A9TB	SKCM	TCGA	VFTTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.1667
p.R520K	DO51297	SKCM	ICGC	VFTTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.1667
p.D423N	DO48366	BLCA	ICGC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.25
p.R518Q	DO229013	COCA	ICGC	VFTTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.1111
p.T437I	DO234230	ESAD	ICGC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.2222
p.S524N	DO23460	LINC	ICGC	VFTTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2778
p.Y420F	DO222418	MELA	ICGC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1667
p.R518W	DO232555	PBCA	ICGC	VFTTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.1111
p.G434W	SIDM01943	Colorectal Carcinoma	GDSC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.3056
p.T528S	SIDM00329	Hodgkin's Lymphoma	GDSC	VFTTS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.6005
p.T528S	ACH-000806	Lymphoma	CCLE	VFTTS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.6005
p.T528S	L-540	haematopoietic and lymphoid tissue	COSMIC	VFTTS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.6005
p.Y420N	SIDM00292	Small Cell Lung Carcinoma	GDSC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1667
p.Y420N	ACH-002077	Lung Cancer	CCLE	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1667
p.Y420N	LU-165	lung	COSMIC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1667
p.P432L	SIDM00511	Small Cell Lung Carcinoma	GDSC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation altering degron motif	0.6471
p.P432L	ACH-000257	Lung Cancer	CCLE	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation altering degron motif	0.6471
p.P432L	COR-L279	lung	COSMIC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation altering degron motif	0.6471
p.F441L	SIDM00837	Colorectal Carcinoma	GDSC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1111
p.F441L	ACH-000455	Brain Cancer	CCLE	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1111
p.F441L	ACH-000958	Colon/Colorectal Cancer	CCLE	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1111
p.F441L	SW48	large intestine	COSMIC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1111
p.P430R	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation altering degron motif	0.7512
p.P430R	ACH-001638	Lymphoma	CCLE	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation altering degron motif	0.7512
p.P430R	RC-K8	haematopoietic and lymphoid tissue	COSMIC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation altering degron motif	0.7512
p.I419N	SIDM01608	Endometrial Carcinoma	GDSC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1389
p.I419N	ACH-000990	Endometrial/Uterine Cancer	CCLE	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1389
p.K417E	EN	endometrium	COSMIC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.0833
p.D439N	NCI-H1770	lung	COSMIC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1667
p.R430H	SNU-C5	large intestine	COSMIC	LTETPCPT	DEG_SCF_FBW7_1	426:433	Mutation altering degron motif	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MEP1A

UniProt ID: Q16819

Entrez ID: 4224

Protein name: Meprin A subunit alpha (EC 3.4.24.18) (Endopeptidase-2) (N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha) (PABA peptide hydrolase) (PPH alpha)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MEP1A in