DegronMD

Uniprot ID: Q16819

Source protein: Meprin A subunit alpha

Source gene: MEP1A

Class: DEG_SPOP_SBC_1

Location: 526:530

E3 ligase: SPOP

DEGRON score: 0.9281

ASA_SCORE: 48.54

COIL: 0.535

CONS_SCORE: 0.3398

DSS_SCORE: 0.4633

HELIX: 0.075

FCONS_SCORE: 1.096

RIG_SCORE: 0.7262

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A537V	TCGA-B5-A11E	UCEC	TCGA	VFTTS	DEG_SPOP_SBC_1	0.1389
p.A537V	DO41644	UCEC	ICGC	VFTTS	DEG_SPOP_SBC_1	0.1389
p.M521V	TCGA-B5-A1MX	UCEC	TCGA	VFTTS	DEG_SPOP_SBC_1	0.1944
p.M521V	DO41999	UCEC	ICGC	VFTTS	DEG_SPOP_SBC_1	0.1944
p.S530L	TCGA-CG-4437	STAD	TCGA	VFTTS	DEG_SPOP_SBC_1	0.8778
p.S530L	DO38467	STAD	ICGC	VFTTS	DEG_SPOP_SBC_1	0.8778
p.M525I	TCGA-DA-A1I0	SKCM	TCGA	VFTTS	DEG_SPOP_SBC_1	0.3056
p.M525I	DO37719	SKCM	ICGC	VFTTS	DEG_SPOP_SBC_1	0.3056
p.M525I	ACH-002463	Non-Cancerous	CCLE	VFTTS	DEG_SPOP_SBC_1	0.3056
p.T534A	TCGA-HJ-7597	STAD	TCGA	VFTTS	DEG_SPOP_SBC_1	0.2222
p.T534A	DO222517	BTCA	ICGC	VFTTS	DEG_SPOP_SBC_1	0.2222
p.T534A	DO38195	STAD	ICGC	VFTTS	DEG_SPOP_SBC_1	0.2222
p.F527L	TCGA-L9-A444	LUAD	TCGA	VFTTS	DEG_SPOP_SBC_1	0.587
p.F527L	DO26015	LUAD	ICGC	VFTTS	DEG_SPOP_SBC_1	0.587
p.R520K	TCGA-YD-A9TB	SKCM	TCGA	VFTTS	DEG_SPOP_SBC_1	0.1667
p.R520K	DO51297	SKCM	ICGC	VFTTS	DEG_SPOP_SBC_1	0.1667
p.R518Q	DO229013	COCA	ICGC	VFTTS	DEG_SPOP_SBC_1	0.1111
p.S524N	DO23460	LINC	ICGC	VFTTS	DEG_SPOP_SBC_1	0.2778
p.R518W	DO232555	PBCA	ICGC	VFTTS	DEG_SPOP_SBC_1	0.1111
p.T528S	SIDM00329	Hodgkin's Lymphoma	GDSC	VFTTS	DEG_SPOP_SBC_1	0.6005
p.T528S	ACH-000806	Lymphoma	CCLE	VFTTS	DEG_SPOP_SBC_1	0.6005
p.T528S	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	VFTTS	DEG_SPOP_SBC_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16819	Meprin A subunit alpha	DEG_SPOP_SBC_1	526:530	VFTTS	SPOP	0.9281	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons