DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 3113:3120

E3 ligase: FBXW7

DEGRON score: 0.7885

ASA_SCORE: 100

COIL: 0.9106

CONS_SCORE: 0

DSS_SCORE: 0.7209

HELIX: 0.0113

FCONS_SCORE: 0

RIG_SCORE: 0.6969

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E3109K	TCGA-D3-A3MR	SKCM	TCGA	LTFTPSET	DEG_SCF_FBW7_1	0.2222
p.E3109K	TCGA-W3-A825	SKCM	TCGA	LTFTPSET	DEG_SCF_FBW7_1	0.2222
p.E3109K	DO47256	SKCM	ICGC	LTFTPSET	DEG_SCF_FBW7_1	0.2222
p.E3109K	DO51272	SKCM	ICGC	LTFTPSET	DEG_SCF_FBW7_1	0.2222
p.T3122A	TCGA-DA-A3F5	SKCM	TCGA	LTFTPSET	DEG_SCF_FBW7_1	0.2778
p.T3122A	DO37435	SKCM	ICGC	LTFTPSET	DEG_SCF_FBW7_1	0.2778
p.E3103K	TCGA-EE-A29H	SKCM	TCGA	LTFTPSET	DEG_SCF_FBW7_1	0.0556
p.E3103K	DO37535	SKCM	ICGC	LTFTPSET	DEG_SCF_FBW7_1	0.0556
p.E3104K	TCGA-FW-A3R5	SKCM	TCGA	LTFTPSET	DEG_SCF_FBW7_1	0.0833
p.E3104K	DO37406	SKCM	ICGC	LTFTPSET	DEG_SCF_FBW7_1	0.0833
p.T3112M	DO222762	COCA	ICGC	LTFTPSET	DEG_SCF_FBW7_1	0.3056
p.L3113I	DO50412	ESAD	ICGC	LTFTPSET	DEG_SCF_FBW7_1	0.6063
p.T3110I	DO229505	LAML	ICGC	LTFTPSET	DEG_SCF_FBW7_1	0.25
p.T3110I	SIDM00217	Colorectal Carcinoma	GDSC	LTFTPSET	DEG_SCF_FBW7_1	0.25
p.T3110I	SNU-1040	large_intestine	COSMIC	LTFTPSET	DEG_SCF_FBW7_1	0.25
p.Q3111L	DO228743	LICA	ICGC	LTFTPSET	DEG_SCF_FBW7_1	0.2778
p.T3120N	DO229015	LICA	ICGC	LTFTPSET	DEG_SCF_FBW7_1	0.7055
p.P3117T	DO229029	LICA	ICGC	LTFTPSET	DEG_SCF_FBW7_1	0.7031
p.Q3111R	DO231613	LINC	ICGC	LTFTPSET	DEG_SCF_FBW7_1	0.2778
p.P3117S	DO220903	MELA	ICGC	LTFTPSET	DEG_SCF_FBW7_1	0.6752
p.P3117S	DO222775	MELA	ICGC	LTFTPSET	DEG_SCF_FBW7_1	0.6752
p.P3121S	DO50684	ORCA	ICGC	LTFTPSET	DEG_SCF_FBW7_1	0.3056
p.Q3111P	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	LTFTPSET	DEG_SCF_FBW7_1	0.2778
p.Q3111P	SIDM00673	Breast Carcinoma	GDSC	LTFTPSET	DEG_SCF_FBW7_1	0.2778
p.P3117L	SIDM00140	Melanoma	GDSC	LTFTPSET	DEG_SCF_FBW7_1	0.7582
p.P3117L	ACH-000968	Skin Cancer	CCLE	LTFTPSET	DEG_SCF_FBW7_1	0.7582
p.P3117L	COLO-792	skin	COSMIC	LTFTPSET	DEG_SCF_FBW7_1	0.7582
p.S3128F	SIDM00273	Glioblastoma	GDSC	LTFTPSET	DEG_SCF_FBW7_1	0.1111
p.S3128F	ACH-000756	Brain Cancer	CCLE	LTFTPSET	DEG_SCF_FBW7_1	0.1111
p.S3128F	GI-1	central_nervous_system	COSMIC	LTFTPSET	DEG_SCF_FBW7_1	0.1111
p.S3129P	ACH-002026	Endometrial/Uterine Cancer	CCLE	LTFTPSET	DEG_SCF_FBW7_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTFTPSET

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of LTFTPSET

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	3113:3120	LTFTPSET	FBXW7	0.7885	More...