DegronMD

Uniprot ID: P28329

Source protein: Choline O-acetyltransferase

Source gene: CHAT

Class: DEG_SCF_FBW7_2

Location: 106:113

E3 ligase: FBXW7

DEGRON score: 0.9565

ASA_SCORE: 74.3875

COIL: 0.6449

CONS_SCORE: -1000

DSS_SCORE: 0.483

HELIX: 0.2894

FCONS_SCORE: 2.0003

RIG_SCORE: 0.7356

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G96V	TCGA-A7-A6VY	BRCA	TCGA	LTKTPILE	DEG_SCF_FBW7_2	0.0556
p.T109M	TCGA-BS-A0UF	UCEC	TCGA	LTKTPILE	DEG_SCF_FBW7_2	0.7423
p.A121V	TCGA-DI-A1BU	UCEC	TCGA	LTKTPILE	DEG_SCF_FBW7_2	0.1111
p.T123N	TCGA-EO-A3B0	UCEC	TCGA	LTKTPILE	DEG_SCF_FBW7_2	0.5
p.R117C	TCGA-FI-A2D5	UCEC	TCGA	LTKTPILE	DEG_SCF_FBW7_2	0.2222
p.H98R	TCGA-FV-A2QQ	LIHC	TCGA	LTKTPILE	DEG_SCF_FBW7_2	0.1111
p.H98R	DO44919	LIHC	ICGC	LTKTPILE	DEG_SCF_FBW7_2	0.1111
p.E113Q	TCGA-IQ-A61I	HNSC	TCGA	LTKTPILE	DEG_SCF_FBW7_2	0.6744
p.E113Q	DO49032	HNSC	ICGC	LTKTPILE	DEG_SCF_FBW7_2	0.6744
p.R117H	DO222454	BTCA	ICGC	LTKTPILE	DEG_SCF_FBW7_2	0.2222
p.R117H	DO227907	COCA	ICGC	LTKTPILE	DEG_SCF_FBW7_2	0.2222
p.R117H	DO234300	ESAD	ICGC	LTKTPILE	DEG_SCF_FBW7_2	0.2222
p.R117H	DO228511	MALY	ICGC	LTKTPILE	DEG_SCF_FBW7_2	0.2222
p.R104Q	DO222928	BTCA	ICGC	LTKTPILE	DEG_SCF_FBW7_2	0.2778
p.K118N	DO222884	COCA	ICGC	LTKTPILE	DEG_SCF_FBW7_2	0.3056
p.S119R	DO229010	COCA	ICGC	LTKTPILE	DEG_SCF_FBW7_2	0.1667
p.V100M	DO21487	LAML	ICGC	LTKTPILE	DEG_SCF_FBW7_2	0.1667
p.A99V	DO22237	LGG	ICGC	LTKTPILE	DEG_SCF_FBW7_2	0.1389
p.A99V	DO50923	LICA	ICGC	LTKTPILE	DEG_SCF_FBW7_2	0.1389
p.S96C	DO26941	LUSC	ICGC	LTKTPILE	DEG_SCF_FBW7_2	0.0556
p.P108S	DO51272	SKCM	ICGC	LTKTPILE	DEG_SCF_FBW7_2	0.6752
p.K114T	SIDM00442	Thyroid Gland Carcinoma	GDSC	LTKTPILE	DEG_SCF_FBW7_2	0.3056
p.K114T	ACH-000058	Thyroid Cancer	CCLE	LTKTPILE	DEG_SCF_FBW7_2	0.3056
p.K114T	ML-1	thyroid	COSMIC	LTKTPILE	DEG_SCF_FBW7_2	0.3056
p.P101S	SW982	soft_tissue	COSMIC	LTKTPILE	DEG_SCF_FBW7_2	0.1944
p.P101L	SW982	soft_tissue	COSMIC	LTKTPILE	DEG_SCF_FBW7_2	0.1944
p.R105Q	SCC-3	haematopoietic_and_lymphoid_tissue	COSMIC	LTKTPILE	DEG_SCF_FBW7_2	0.3056
p.R105Q	PC-14	lung	COSMIC	LTKTPILE	DEG_SCF_FBW7_2	0.3056
p.P99L	NCI-H2227	lung	COSMIC	LTKTPILE	DEG_SCF_FBW7_2	0.1389
p.R104P	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	LTKTPILE	DEG_SCF_FBW7_2	0.2778
p.T96I	SK-MEL-5	skin	COSMIC	LTKTPILE	DEG_SCF_FBW7_2	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTKTPILE

Degron related mutations and impact score

Drug responses associated with CHAT mutations

All proteins holding degron of LTKTPILE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28329	Choline O-acetyltransferase	DEG_SCF_FBW7_2	106:113	LTKTPILE	FBXW7	0.9565	More...