DegronMD - P28329(CHAT)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G96V	TCGA-A7-A6VY	BRCA	TCGA	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.0556
p.T109M	TCGA-BS-A0UF	UCEC	TCGA	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation altering degron motif	0.7423
p.A121V	TCGA-DI-A1BU	UCEC	TCGA	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.1111
p.T123N	TCGA-EO-A3B0	UCEC	TCGA	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation blocking phosphorylation signal	0.5
p.R117C	TCGA-FI-A2D5	UCEC	TCGA	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.2222
p.H98R	TCGA-FV-A2QQ	LIHC	TCGA	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.1111
p.H98R	DO44919	LIHC	ICGC	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.1111
p.E113Q	TCGA-IQ-A61I	HNSC	TCGA	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation altering degron motif	0.6744
p.E113Q	DO49032	HNSC	ICGC	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation altering degron motif	0.6744
p.R117H	DO222454	BTCA	ICGC	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.2222
p.R117H	DO227907	COCA	ICGC	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.2222
p.R117H	DO234300	ESAD	ICGC	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.2222
p.R117H	DO228511	MALY	ICGC	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.2222
p.R104Q	DO222928	BTCA	ICGC	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.2778
p.K118N	DO222884	COCA	ICGC	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation substituting flanking lysine	0.3056
p.S119R	DO229010	COCA	ICGC	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.1667
p.A73S	DO233276	GACA	ICGC	PAHTPAHT	DEG_SCF_FBW7_1	71:78	Mutation altering degron motif	0.7588
p.W80G	DO15847	HNSC	ICGC	PAHTPAHT	DEG_SCF_FBW7_1	71:78	Mutation rewiring degron network	0.2778
p.V100M	DO21487	LAML	ICGC	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.1667
p.A99V	DO22237	LGG	ICGC	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.1389
p.A99V	DO50923	LICA	ICGC	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.1389
p.Q63K	DO25396	LUAD	ICGC	PAHTPAHT	DEG_SCF_FBW7_1	71:78	Mutation rewiring degron network	0.1111
p.S96C	DO26941	LUSC	ICGC	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.0556
p.Q69K	DO26752	LUSC	ICGC	PAHTPAHT	DEG_SCF_FBW7_1	71:78	Mutation rewiring degron network	0.2778
p.S86L	DO228236	MALY	ICGC	PAHTPAHT	DEG_SCF_FBW7_1	71:78	Mutation rewiring degron network	0.1111
p.R68P	DO228338	MALY	ICGC	PAHTPAHT	DEG_SCF_FBW7_1	71:78	Mutation rewiring degron network	0.25
p.R68P	DG-75	haematopoietic and lymphoid tissue	COSMIC	PAHTPAHT	DEG_SCF_FBW7_1	71:78	Mutation rewiring degron network	0.25
p.P68S	DO222420	MELA	ICGC	PAHTPAHT	DEG_SCF_FBW7_1	71:78	Mutation rewiring degron network	0.25
p.N88T	DO222702	MELA	ICGC	PAHTPAHT	DEG_SCF_FBW7_1	71:78	Mutation rewiring degron network	0.0556
p.P68L	DO46513	OV	ICGC	PAHTPAHT	DEG_SCF_FBW7_1	71:78	Mutation rewiring degron network	0.25
p.P75L	DO229453	SKCA	ICGC	PAHTPAHT	DEG_SCF_FBW7_1	71:78	Mutation altering degron motif	0.7582
p.P108S	DO51272	SKCM	ICGC	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation altering degron motif	0.6752
p.K114T	SIDM00442	Thyroid Gland Carcinoma	GDSC	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.3056
p.K114T	ACH-000058	Thyroid Cancer	CCLE	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.3056
p.K114T	ML-1	thyroid	COSMIC	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.3056
p.P101S	SW982	soft tissue	COSMIC	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.1944
p.A62V	SNU-1040	large intestine	COSMIC	PAHTPAHT	DEG_SCF_FBW7_1	71:78	Mutation rewiring degron network	0.0833
p.P101L	SW982	soft tissue	COSMIC	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.1944
p.P65Q	DU-145	prostate	COSMIC	PAHTPAHT	DEG_SCF_FBW7_1	71:78	Mutation rewiring degron network	0.1667
p.R105Q	SCC-3	haematopoietic and lymphoid tissue	COSMIC	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.3056
p.R105Q	PC-14	lung	COSMIC	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.3056
p.S86R	HCC-366	lung	COSMIC	PAHTPAHT	DEG_SCF_FBW7_1	71:78	Mutation rewiring degron network	0.1111
p.P99L	NCI-H2227	lung	COSMIC	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.1389
p.E62K	NUGC-3	stomach	COSMIC	PAHTPAHT	DEG_SCF_FBW7_1	71:78	Mutation rewiring degron network	0.0833
p.R104P	DG-75	haematopoietic and lymphoid tissue	COSMIC	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.2778
p.T96I	SK-MEL-5	skin	COSMIC	LTKTPILE	DEG_SCF_FBW7_2	106:113	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHAT

UniProt ID: P28329

Entrez ID: 1103

Protein name: Choline O-acetyltransferase (CHOACTase) (ChAT) (Choline acetylase) (EC 2.3.1.6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHAT in