DegronMD

Uniprot ID: P28329

Source protein: Choline O-acetyltransferase

Source gene: CHAT

Class: DEG_SCF_FBW7_1

Location: 71:78

E3 ligase: FBXW7

DEGRON score: 0.9908

ASA_SCORE: 77.9

COIL: 0.9274

CONS_SCORE: 0.2229

DSS_SCORE: 0.5944

HELIX: 0.0361

FCONS_SCORE: 0.9906

RIG_SCORE: 0.5991

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A73S	DO233276	GACA	ICGC	PAHTPAHT	DEG_SCF_FBW7_1	0.7588
p.W80G	DO15847	HNSC	ICGC	PAHTPAHT	DEG_SCF_FBW7_1	0.2778
p.Q63K	DO25396	LUAD	ICGC	PAHTPAHT	DEG_SCF_FBW7_1	0.1111
p.Q69K	DO26752	LUSC	ICGC	PAHTPAHT	DEG_SCF_FBW7_1	0.2778
p.S86L	DO228236	MALY	ICGC	PAHTPAHT	DEG_SCF_FBW7_1	0.1111
p.R68P	DO228338	MALY	ICGC	PAHTPAHT	DEG_SCF_FBW7_1	0.25
p.R68P	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	PAHTPAHT	DEG_SCF_FBW7_1	0.25
p.P68S	DO222420	MELA	ICGC	PAHTPAHT	DEG_SCF_FBW7_1	0.25
p.N88T	DO222702	MELA	ICGC	PAHTPAHT	DEG_SCF_FBW7_1	0.0556
p.P68L	DO46513	OV	ICGC	PAHTPAHT	DEG_SCF_FBW7_1	0.25
p.P75L	DO229453	SKCA	ICGC	PAHTPAHT	DEG_SCF_FBW7_1	0.7582
p.A62V	SNU-1040	large_intestine	COSMIC	PAHTPAHT	DEG_SCF_FBW7_1	0.0833
p.P65Q	DU-145	prostate	COSMIC	PAHTPAHT	DEG_SCF_FBW7_1	0.1667
p.S86R	HCC-366	lung	COSMIC	PAHTPAHT	DEG_SCF_FBW7_1	0.1111
p.E62K	NUGC-3	stomach	COSMIC	PAHTPAHT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28329	Choline O-acetyltransferase	DEG_SCF_FBW7_1	71:78	PAHTPAHT	FBXW7	0.9908	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons