DegronMD

Uniprot ID: Q6UB99

Source protein: Ankyrin repeat domain-containing protein 11

Source gene: ANKRD11

Class: DEG_SCF_FBW7_2

Location: 36:43

E3 ligase: FBXW7

DEGRON score: 0.9758

ASA_SCORE: 96.7

COIL: 0.9231

CONS_SCORE: 0.4467

DSS_SCORE: 0.6397

HELIX: 0.0465

FCONS_SCORE: 1.0663

RIG_SCORE: 0.7146

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K29N	TCGA-B5-A1MX	UCEC	TCGA	LTKTPKLE	DEG_SCF_FBW7_2	0.25
p.L36V	TCGA-CR-7374	HNSC	TCGA	LTKTPKLE	DEG_SCF_FBW7_2	0.5654
p.L36V	DO15334	HNSC	ICGC	LTKTPKLE	DEG_SCF_FBW7_2	0.5654
p.R52M	DO229229	THCA	ICGC	LTKTPKLE	DEG_SCF_FBW7_2	0.0833
p.D32Y	SIDM00282	Colorectal Carcinoma	GDSC	LTKTPKLE	DEG_SCF_FBW7_2	0.2222
p.D32Y	ACH-000998	Colon/Colorectal Cancer	CCLE	LTKTPKLE	DEG_SCF_FBW7_2	0.2222
p.D32Y	CW-2	large_intestine	COSMIC	LTKTPKLE	DEG_SCF_FBW7_2	0.2222
p.D46N	SIDM00878	Breast Carcinoma	GDSC	LTKTPKLE	DEG_SCF_FBW7_2	0.25
p.K31E	SIDM00357	Small Cell Lung Carcinoma	GDSC	LTKTPKLE	DEG_SCF_FBW7_2	0.3056
p.K31E	ACH-002193	Lung Cancer	CCLE	LTKTPKLE	DEG_SCF_FBW7_2	0.3056
p.K31E	RERF-LC-FM	lung	COSMIC	LTKTPKLE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UB99	Ankyrin repeat domain-containing protein 11	DEG_SCF_FBW7_2	36:43	LTKTPKLE	FBXW7	0.9758	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons