DegronMD

Uniprot ID: Q9H9L3

Source protein: Interferon-stimulated 20 kDa exonuclease-like 2

Source gene: ISG20L2

Class: DEG_SCF_FBW7_1

Location: 101:106

E3 ligase: FBXW7

DEGRON score: 0.9743

ASA_SCORE: 91.2333

COIL: 0.9522

CONS_SCORE: 0.4179

DSS_SCORE: 0.4203

HELIX: 0.0288

FCONS_SCORE: 1.0182

RIG_SCORE: 0.7156

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P103L	TCGA-FW-A3R5	SKCM	TCGA	LTPAPS	DEG_SCF_FBW7_1	0.7582
p.P103L	DO37406	SKCM	ICGC	LTPAPS	DEG_SCF_FBW7_1	0.7582
p.P91H	DO229032	LICA	ICGC	LTPAPS	DEG_SCF_FBW7_1	0.0556
p.W100L	DO23204	LINC	ICGC	LTPAPS	DEG_SCF_FBW7_1	0.3056
p.T102I	DO232224	PBCA	ICGC	LTPAPS	DEG_SCF_FBW7_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H9L3	Interferon-stimulated 20 kDa exonuclease-like 2	DEG_SCF_FBW7_1	101:106	LTPAPS	FBXW7	0.9743	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons