DegronMD

Uniprot ID: Q6ZWH5

Source protein: Serine/threonine-protein kinase Nek10

Source gene: NEK10

Class: DEG_SCF_FBW7_2

Location: 766:771

E3 ligase: FBXW7

DEGRON score: 0.7188

ASA_SCORE: 63.5

COIL: 0.7685

CONS_SCORE: 0.4837

DSS_SCORE: 0.3648

HELIX: 0.209

FCONS_SCORE: 1.0877

RIG_SCORE: 0.7935

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P768A	TCGA-51-6867	LUSC	TCGA	LTPDAE	DEG_SCF_FBW7_2	0.7503
p.E771K	TCGA-EB-A3XD	SKCM	TCGA	LTPDAE	DEG_SCF_FBW7_2	0.7022
p.D769V	ACH-000070	Leukemia	CCLE	LTPDAE	DEG_SCF_FBW7_2	0.6674
p.D769V	697	haematopoietic_and_lymphoid_tissue	COSMIC	LTPDAE	DEG_SCF_FBW7_2	0.6674
p.L766P	ACH-000990	Endometrial/Uterine Cancer	CCLE	LTPDAE	DEG_SCF_FBW7_2	0.6471
p.R773C	ACH-002388	Skin Cancer	CCLE	LTPDAE	DEG_SCF_FBW7_2	0.2778
p.S781L	TCGA-19-5956	GBM	TCGA	LTPDAE	DEG_SCF_FBW7_2	0.0556
p.S781L	TCGA-AJ-A3EL	UCEC	TCGA	LTPDAE	DEG_SCF_FBW7_2	0.0556
p.S781L	TCGA-AX-A06F	UCEC	TCGA	LTPDAE	DEG_SCF_FBW7_2	0.0556
p.S781L	TCGA-D1-A16X	UCEC	TCGA	LTPDAE	DEG_SCF_FBW7_2	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZWH5	Serine/threonine-protein kinase Nek10	DEG_SCF_FBW7_2	766:771	LTPDAE	FBXW7	0.7188	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons