DegronMD - Q6ZWH5(NEK10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S781L	TCGA-19-5956	GBM	TCGA	LTPDAE	DEG_SCF_FBW7_2	766:771	Mutation rewiring degron network	0.0556
p.S781L	TCGA-AJ-A3EL	UCEC	TCGA	LTPDAE	DEG_SCF_FBW7_2	766:771	Mutation rewiring degron network	0.0556
p.S781L	TCGA-AX-A06F	UCEC	TCGA	LTPDAE	DEG_SCF_FBW7_2	766:771	Mutation rewiring degron network	0.0556
p.S781L	TCGA-D1-A16X	UCEC	TCGA	LTPDAE	DEG_SCF_FBW7_2	766:771	Mutation rewiring degron network	0.0556
p.D962N	TCGA-49-6742	LUAD	TCGA	PRPALLPLD	DEG_APCC_DBOX_1	954:962	Mutation altering degron motif	0.5821
p.P768A	TCGA-51-6867	LUSC	TCGA	LTPDAE	DEG_SCF_FBW7_2	766:771	Mutation altering degron motif	0.7503
p.D945A	TCGA-AP-A1DV	UCEC	TCGA	PRPALLPLD	DEG_APCC_DBOX_1	954:962	Mutation rewiring degron network	0.0833
p.S952L	TCGA-CU-A5W6	BLCA	TCGA	PRPALLPLD	DEG_APCC_DBOX_1	954:962	Mutation rewiring degron network	0.2778
p.T947I	TCGA-E1-A7YO	LGG	TCGA	PRPALLPLD	DEG_APCC_DBOX_1	954:962	Mutation rewiring degron network	0.1389
p.E771K	TCGA-EB-A3XD	SKCM	TCGA	LTPDAE	DEG_SCF_FBW7_2	766:771	Mutation altering degron motif	0.7022
p.A957V	TCGA-FW-A3R5	SKCM	TCGA	PRPALLPLD	DEG_APCC_DBOX_1	954:962	Mutation altering degron motif	0.5825
p.D769V	ACH-000070	Leukemia	CCLE	LTPDAE	DEG_SCF_FBW7_2	766:771	Mutation altering degron motif	0.6674
p.D769V	697	haematopoietic and lymphoid tissue	COSMIC	LTPDAE	DEG_SCF_FBW7_2	766:771	Mutation altering degron motif	0.6674
p.L972F	ACH-000989	Colon/Colorectal Cancer	CCLE	PRPALLPLD	DEG_APCC_DBOX_1	954:962	Mutation rewiring degron network	0.0556
p.L972F	SNU-175	large intestine	COSMIC	PRPALLPLD	DEG_APCC_DBOX_1	954:962	Mutation rewiring degron network	0.0556
p.L766P	ACH-000990	Endometrial/Uterine Cancer	CCLE	LTPDAE	DEG_SCF_FBW7_2	766:771	Mutation altering degron motif	0.6471
p.R773C	ACH-002388	Skin Cancer	CCLE	LTPDAE	DEG_SCF_FBW7_2	766:771	Mutation rewiring degron network	0.2778

Kaplan plot for NEK10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NEK10

UniProt ID: Q6ZWH5

Entrez ID: 152110

Protein name: Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (Never in mitosis A-related kinase 10) (NimA-related protein kinase 10)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NEK10 in