DegronMD

Uniprot ID: Q6ZWH5

Source protein: Serine/threonine-protein kinase Nek10

Source gene: NEK10

Class: DEG_APCC_DBOX_1

Location: 954:962

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9854

ASA_SCORE: 83.3333

COIL: 0.7574

CONS_SCORE: 0.362

DSS_SCORE: 0.4035

HELIX: 0.2152

FCONS_SCORE: 1.0631

RIG_SCORE: 0.7697

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D962N	TCGA-49-6742	LUAD	TCGA	PRPALLPLD	DEG_APCC_DBOX_1	0.5821
p.D945A	TCGA-AP-A1DV	UCEC	TCGA	PRPALLPLD	DEG_APCC_DBOX_1	0.0833
p.S952L	TCGA-CU-A5W6	BLCA	TCGA	PRPALLPLD	DEG_APCC_DBOX_1	0.2778
p.T947I	TCGA-E1-A7YO	LGG	TCGA	PRPALLPLD	DEG_APCC_DBOX_1	0.1389
p.A957V	TCGA-FW-A3R5	SKCM	TCGA	PRPALLPLD	DEG_APCC_DBOX_1	0.5825
p.L972F	ACH-000989	Colon/Colorectal Cancer	CCLE	PRPALLPLD	DEG_APCC_DBOX_1	0.0556
p.L972F	SNU-175	large_intestine	COSMIC	PRPALLPLD	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZWH5	Serine/threonine-protein kinase Nek10	DEG_APCC_DBOX_1	954:962	PRPALLPLD	APC,CDC20,FZR1	0.9854	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons