DegronMD

Uniprot ID: Q7Z6K5

Source protein: Arpin

Source gene: ARPIN

Class: DEG_SCF_FBW7_1

Location: 132:137

E3 ligase: FBXW7

DEGRON score: 0.923

ASA_SCORE: 52.9167

COIL: 0.7395

CONS_SCORE: 0.4492

DSS_SCORE: 0.3211

HELIX: 0.1312

FCONS_SCORE: 0.8802

RIG_SCORE: 0.7736

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A127V	SIDM00128	Head and Neck Carcinoma	GDSC	LTPDHT	DEG_SCF_FBW7_1	0.1944
p.A127V	JHU-011	upper_aerodigestive_tract	COSMIC	LTPDHT	DEG_SCF_FBW7_1	0.1944
p.A139V	SIDM00660	Colorectal Carcinoma	GDSC	LTPDHT	DEG_SCF_FBW7_1	0.2778
p.A139V	SIDM00869	Non-Cancerous	GDSC	LTPDHT	DEG_SCF_FBW7_1	0.2778
p.D135N	SIDM00998	Glioblastoma	GDSC	LTPDHT	DEG_SCF_FBW7_1	0.5821
p.D135N	SIDM01554	Mesothelioma	GDSC	LTPDHT	DEG_SCF_FBW7_1	0.5821
p.A123T	OVCAR-4	ovary	COSMIC	LTPDHT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z6K5	Arpin	DEG_SCF_FBW7_1	132:137	LTPDHT	FBXW7	0.923	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons