DegronMD

Uniprot ID: Q8TBN0

Source protein: Guanine nucleotide exchange factor for Rab-3A

Source gene: RAB3IL1

Class: DEG_SCF_FBW7_2

Location: 211:216

E3 ligase: FBXW7

DEGRON score: 0.7112

ASA_SCORE: 84.9667

COIL: 0.7293

CONS_SCORE: 0.4818

DSS_SCORE: 0.4563

HELIX: 0.1083

FCONS_SCORE: 1.0463

RIG_SCORE: 0.7335

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A206T	TCGA-AA-A010	COAD	TCGA	LTPDRE	DEG_SCF_FBW7_2	0.1944
p.V220L	TCGA-AP-A1DV	UCEC	TCGA	LTPDRE	DEG_SCF_FBW7_2	0.2222
p.V220L	DO43186	UCEC	ICGC	LTPDRE	DEG_SCF_FBW7_2	0.2222
p.A207V	DO228963	LICA	ICGC	LTPDRE	DEG_SCF_FBW7_2	0.2222
p.A207V	ACH-000982	Colon/Colorectal Cancer	CCLE	LTPDRE	DEG_SCF_FBW7_2	0.2222
p.A207V	ACH-001345	Colon/Colorectal Cancer	CCLE	LTPDRE	DEG_SCF_FBW7_2	0.2222
p.T212N	DO229015	LICA	ICGC	LTPDRE	DEG_SCF_FBW7_2	0.8166
p.D214E	DO229015	LICA	ICGC	LTPDRE	DEG_SCF_FBW7_2	0.5647
p.A206S	DO229229	THCA	ICGC	LTPDRE	DEG_SCF_FBW7_2	0.1944
p.P205R	SIDM01261	Breast Carcinoma	GDSC	LTPDRE	DEG_SCF_FBW7_2	0.1667
p.A202T	SIDM00613	Glioblastoma	GDSC	LTPDRE	DEG_SCF_FBW7_2	0.0833
p.A202T	ACH-000231	Brain Cancer	CCLE	LTPDRE	DEG_SCF_FBW7_2	0.0833
p.A202T	ACH-000967	Colon/Colorectal Cancer	CCLE	LTPDRE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBN0	Guanine nucleotide exchange factor for Rab-3A	DEG_SCF_FBW7_2	211:216	LTPDRE	FBXW7	0.7112	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons