DegronMD - Q8TBN0(RAB3IL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A206T	TCGA-AA-A010	COAD	TCGA	LTPDRE	DEG_SCF_FBW7_2	211:216	Mutation rewiring degron network	0.1944
p.V220L	TCGA-AP-A1DV	UCEC	TCGA	LTPDRE	DEG_SCF_FBW7_2	211:216	Mutation rewiring degron network	0.2222
p.V220L	DO43186	UCEC	ICGC	LTPDRE	DEG_SCF_FBW7_2	211:216	Mutation rewiring degron network	0.2222
p.R171C	DO233882	GACA	ICGC	VITST	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1667
p.R171C	SIDM00217	Colorectal Carcinoma	GDSC	VITST	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1667
p.R171C	ACH-000999	Colon/Colorectal Cancer	CCLE	VITST	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1667
p.A207V	DO228963	LICA	ICGC	LTPDRE	DEG_SCF_FBW7_2	211:216	Mutation rewiring degron network	0.2222
p.A207V	ACH-000982	Colon/Colorectal Cancer	CCLE	LTPDRE	DEG_SCF_FBW7_2	211:216	Mutation rewiring degron network	0.2222
p.A207V	ACH-001345	Colon/Colorectal Cancer	CCLE	LTPDRE	DEG_SCF_FBW7_2	211:216	Mutation rewiring degron network	0.2222
p.T212N	DO229015	LICA	ICGC	LTPDRE	DEG_SCF_FBW7_2	211:216	Mutation altering degron motif	0.8166
p.D214E	DO229015	LICA	ICGC	LTPDRE	DEG_SCF_FBW7_2	211:216	Mutation altering degron motif	0.5647
p.N170K	DO229026	LICA	ICGC	VITST	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1944
p.S164F	DO229051	LICA	ICGC	VITST	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.9093
p.H174P	DO218908	SKCA	ICGC	VITST	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.0833
p.A206S	DO229229	THCA	ICGC	LTPDRE	DEG_SCF_FBW7_2	211:216	Mutation rewiring degron network	0.1944
p.P205R	SIDM01261	Breast Carcinoma	GDSC	LTPDRE	DEG_SCF_FBW7_2	211:216	Mutation rewiring degron network	0.1667
p.A202T	SIDM00613	Glioblastoma	GDSC	LTPDRE	DEG_SCF_FBW7_2	211:216	Mutation rewiring degron network	0.0833
p.A202T	ACH-000231	Brain Cancer	CCLE	LTPDRE	DEG_SCF_FBW7_2	211:216	Mutation rewiring degron network	0.0833
p.A202T	ACH-000967	Colon/Colorectal Cancer	CCLE	LTPDRE	DEG_SCF_FBW7_2	211:216	Mutation rewiring degron network	0.0833
p.T163M	SIDM01010	T-Cell Non-Hodgkin's Lymphoma	GDSC	VITST	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7423
p.T163M	ACH-000053	Lymphoma	CCLE	VITST	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7423
p.T162M	SNU-407	large intestine	COSMIC	VITST	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7423

Kaplan plot for RAB3IL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAB3IL1

UniProt ID: Q8TBN0

Entrez ID: 5866

Protein name: Guanine nucleotide exchange factor for Rab-3A (Rab-3A-interacting-like protein 1) (Rab3A-interacting-like protein 1) (Rabin3-like 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RAB3IL1 in