DegronMD

Uniprot ID: Q8TBN0

Source protein: Guanine nucleotide exchange factor for Rab-3A

Source gene: RAB3IL1

Class: DEG_SPOP_SBC_1

Location: 161:165

E3 ligase: SPOP

DEGRON score: 0.9826

ASA_SCORE: 77.34

COIL: 0.7544

CONS_SCORE: 0.4892

DSS_SCORE: 0.4817

HELIX: 0.1696

FCONS_SCORE: 0.8626

RIG_SCORE: 0.7686

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R171C	DO233882	GACA	ICGC	VITST	DEG_SPOP_SBC_1	0.1667
p.R171C	SIDM00217	Colorectal Carcinoma	GDSC	VITST	DEG_SPOP_SBC_1	0.1667
p.R171C	ACH-000999	Colon/Colorectal Cancer	CCLE	VITST	DEG_SPOP_SBC_1	0.1667
p.N170K	DO229026	LICA	ICGC	VITST	DEG_SPOP_SBC_1	0.1944
p.S164F	DO229051	LICA	ICGC	VITST	DEG_SPOP_SBC_1	0.9093
p.H174P	DO218908	SKCA	ICGC	VITST	DEG_SPOP_SBC_1	0.0833
p.T163M	SIDM01010	T-Cell Non-Hodgkin's Lymphoma	GDSC	VITST	DEG_SPOP_SBC_1	0.7423
p.T163M	ACH-000053	Lymphoma	CCLE	VITST	DEG_SPOP_SBC_1	0.7423
p.T162M	SNU-407	large_intestine	COSMIC	VITST	DEG_SPOP_SBC_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	306:310	VITST	SPOP	0.8673	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3965:3969	VITST	SPOP	0.6873	More...
Q8TBN0	Guanine nucleotide exchange factor for Rab-3A	DEG_SPOP_SBC_1	161:165	VITST	SPOP	0.9826	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6333:6337	VITST	SPOP	0.9371	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8088:8092	VITST	SPOP	0.9495	More...
Q6AHZ1	Zinc finger protein 518A	DEG_SPOP_SBC_1	1207:1211	VITST	SPOP	0.8555	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons