DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 6333:6337

E3 ligase: SPOP

DEGRON score: 0.9371

ASA_SCORE: 80.32

COIL: 0.7716

CONS_SCORE: 0

DSS_SCORE: 0.3077

HELIX: 0.0188

FCONS_SCORE: 0

RIG_SCORE: 0.7692

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V6333F	TCGA-56-A62T	LUSC	TCGA	VITST	DEG_SPOP_SBC_1	0.7068
p.V6333F	DO219144	LUSC	ICGC	VITST	DEG_SPOP_SBC_1	0.7068
p.A6331T	TCGA-AJ-A3EK	UCEC	TCGA	VITST	DEG_SPOP_SBC_1	0.2778
p.A6331T	TCGA-FI-A2D5	UCEC	TCGA	VITST	DEG_SPOP_SBC_1	0.2778
p.A6331T	DO41584	UCEC	ICGC	VITST	DEG_SPOP_SBC_1	0.2778
p.A6331T	DO41331	UCEC	ICGC	VITST	DEG_SPOP_SBC_1	0.2778
p.D6324N	TCGA-CR-7371	HNSC	TCGA	VITST	DEG_SPOP_SBC_1	0.0833
p.D6324N	DO15454	HNSC	ICGC	VITST	DEG_SPOP_SBC_1	0.0833
p.I6334T	TCGA-FI-A2D5	UCEC	TCGA	VITST	DEG_SPOP_SBC_1	0.5966
p.I6334T	DO41331	UCEC	ICGC	VITST	DEG_SPOP_SBC_1	0.5966
p.S6344F	TCGA-GN-A8LK	SKCM	TCGA	VITST	DEG_SPOP_SBC_1	0.1389
p.S6344F	DO51259	SKCM	ICGC	VITST	DEG_SPOP_SBC_1	0.1389
p.T6329R	DO234231	ESAD	ICGC	VITST	DEG_SPOP_SBC_1	0.2222
p.P6325T	DO229028	LICA	ICGC	VITST	DEG_SPOP_SBC_1	0.1111
p.P6325T	DO35561	PBCA	ICGC	VITST	DEG_SPOP_SBC_1	0.1111
p.P6325L	DO222880	MELA	ICGC	VITST	DEG_SPOP_SBC_1	0.1111
p.T6337I	SIDM00057	Neuroblastoma	GDSC	VITST	DEG_SPOP_SBC_1	0.7078
p.T6337I	ACH-000676	Brain Cancer	CCLE	VITST	DEG_SPOP_SBC_1	0.7078
p.T6337I	ACH-002389	Neuroblastoma	CCLE	VITST	DEG_SPOP_SBC_1	0.7078
p.T6337I	ACN	autonomic_ganglia	COSMIC	VITST	DEG_SPOP_SBC_1	0.7078
p.T6329I	SIDM00002	Neuroblastoma	GDSC	VITST	DEG_SPOP_SBC_1	0.2222
p.T6329I	ACH-002340	Neuroblastoma	CCLE	VITST	DEG_SPOP_SBC_1	0.2222
p.T6329I	NBsusSR	autonomic_ganglia	COSMIC	VITST	DEG_SPOP_SBC_1	0.2222
p.V6333A	SIDM01052	Ovarian Carcinoma	GDSC	VITST	DEG_SPOP_SBC_1	0.5825
p.V6333A	ACH-000308	Ovarian Cancer	CCLE	VITST	DEG_SPOP_SBC_1	0.5825
p.V6333A	EFO-21	ovary	COSMIC	VITST	DEG_SPOP_SBC_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	306:310	VITST	SPOP	0.8673	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3965:3969	VITST	SPOP	0.6873	More...
Q8TBN0	Guanine nucleotide exchange factor for Rab-3A	DEG_SPOP_SBC_1	161:165	VITST	SPOP	0.9826	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6333:6337	VITST	SPOP	0.9371	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8088:8092	VITST	SPOP	0.9495	More...
Q6AHZ1	Zinc finger protein 518A	DEG_SPOP_SBC_1	1207:1211	VITST	SPOP	0.8555	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons