DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VITST
Uniprot ID:
Q6AHZ1
Source protein:
Zinc finger protein 518A
Source gene:
ZNF518A
Class:
DEG_SPOP_SBC_1
Location:
1207:1211
E3 ligase:
SPOP
DEGRON score:
0.8555
ASA_SCORE:
56.9
COIL:
0.4506
CONS_SCORE:
0.3734
DSS_SCORE:
0.4258
HELIX:
0.0196
FCONS_SCORE:
0.8329
RIG_SCORE:
0.7983
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ZNF518A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VITST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q685J3
Mucin-17
DEG_SPOP_SBC_1
306:310
VITST
SPOP
0.8673
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
3965:3969
VITST
SPOP
0.6873
More...
Q8TBN0
Guanine nucleotide exchange factor for Rab-3A
DEG_SPOP_SBC_1
161:165
VITST
SPOP
0.9826
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
6333:6337
VITST
SPOP
0.9371
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
8088:8092
VITST
SPOP
0.9495
More...
Q6AHZ1
Zinc finger protein 518A
DEG_SPOP_SBC_1
1207:1211
VITST
SPOP
0.8555
More...