DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 306:310

E3 ligase: SPOP

DEGRON score: 0.8673

ASA_SCORE: 85.26

COIL: 0.8036

CONS_SCORE: 0.5236

DSS_SCORE: 0.5243

HELIX: 0.011

FCONS_SCORE: 1

RIG_SCORE: 0.7671

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T318M	TCGA-16-0850	GBM	TCGA	VITST	DEG_SPOP_SBC_1	0.1111
p.T318M	TCGA-V5-AASX	ESCA	TCGA	VITST	DEG_SPOP_SBC_1	0.1111
p.T318M	TCGA-VQ-AA68	STAD	TCGA	VITST	DEG_SPOP_SBC_1	0.1111
p.T318M	DO12160	GBM	ICGC	VITST	DEG_SPOP_SBC_1	0.1111
p.T318M	DO51799	STAD	ICGC	VITST	DEG_SPOP_SBC_1	0.1111
p.P316L	TCGA-A5-A0GB	UCEC	TCGA	VITST	DEG_SPOP_SBC_1	0.1667
p.P316L	DO41434	UCEC	ICGC	VITST	DEG_SPOP_SBC_1	0.1667
p.A319D	TCGA-AX-A06F	UCEC	TCGA	VITST	DEG_SPOP_SBC_1	0.0833
p.A319D	DO41752	UCEC	ICGC	VITST	DEG_SPOP_SBC_1	0.0833
p.I304F	TCGA-D9-A6EC	SKCM	TCGA	VITST	DEG_SPOP_SBC_1	0.2778
p.I304F	DO50291	SKCM	ICGC	VITST	DEG_SPOP_SBC_1	0.2778
p.N303S	TCGA-EM-A2P0	THCA	TCGA	VITST	DEG_SPOP_SBC_1	0.25
p.N303S	DO39622	THCA	ICGC	VITST	DEG_SPOP_SBC_1	0.25
p.S313I	TCGA-NC-A5HR	LUSC	TCGA	VITST	DEG_SPOP_SBC_1	0.25
p.S313I	DO219203	LUSC	ICGC	VITST	DEG_SPOP_SBC_1	0.25
p.A312T	DO228483	BRCA	ICGC	VITST	DEG_SPOP_SBC_1	0.2778
p.I307T	DO228950	LICA	ICGC	VITST	DEG_SPOP_SBC_1	0.5966
p.S313T	DO229050	LICA	ICGC	VITST	DEG_SPOP_SBC_1	0.25
p.P305L	DO231909	LINC	ICGC	VITST	DEG_SPOP_SBC_1	0.3056
p.T317I	DO224566	LUSC	ICGC	VITST	DEG_SPOP_SBC_1	0.1389
p.T317I	DO231007	LUSC	ICGC	VITST	DEG_SPOP_SBC_1	0.1389
p.S313N	SIDM00565	Oral Cavity Carcinoma	GDSC	VITST	DEG_SPOP_SBC_1	0.25
p.S313N	ACH-001626	Head and Neck Cancer	CCLE	VITST	DEG_SPOP_SBC_1	0.25
p.S313N	OSC-20	upper_aerodigestive_tract	COSMIC	VITST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	306:310	VITST	SPOP	0.8673	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3965:3969	VITST	SPOP	0.6873	More...
Q8TBN0	Guanine nucleotide exchange factor for Rab-3A	DEG_SPOP_SBC_1	161:165	VITST	SPOP	0.9826	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6333:6337	VITST	SPOP	0.9371	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8088:8092	VITST	SPOP	0.9495	More...
Q6AHZ1	Zinc finger protein 518A	DEG_SPOP_SBC_1	1207:1211	VITST	SPOP	0.8555	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons