DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 3965:3969

E3 ligase: SPOP

DEGRON score: 0.6873

ASA_SCORE: 89.46

COIL: 0.8184

CONS_SCORE: 0.5236

DSS_SCORE: 0.5103

HELIX: 0.0114

FCONS_SCORE: 0.8608

RIG_SCORE: 0.7817

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A3956E	TCGA-39-5030	LUSC	TCGA	VITST	DEG_SPOP_SBC_1	0.0833
p.A3956E	DO7418	CLLE	ICGC	VITST	DEG_SPOP_SBC_1	0.0833
p.A3956E	DO27176	LUSC	ICGC	VITST	DEG_SPOP_SBC_1	0.0833
p.I3966M	TCGA-78-7147	LUAD	TCGA	VITST	DEG_SPOP_SBC_1	0.6507
p.I3966M	DO24527	LUAD	ICGC	VITST	DEG_SPOP_SBC_1	0.6507
p.T3957I	TCGA-AA-A01I	COAD	TCGA	VITST	DEG_SPOP_SBC_1	0.1111
p.T3957I	DO10510	COAD	ICGC	VITST	DEG_SPOP_SBC_1	0.1111
p.T3967A	TCGA-EE-A20C	SKCM	TCGA	VITST	DEG_SPOP_SBC_1	0.7139
p.T3967A	DO222775	MELA	ICGC	VITST	DEG_SPOP_SBC_1	0.7139
p.T3967A	DO47665	SKCM	ICGC	VITST	DEG_SPOP_SBC_1	0.7139
p.V3965L	DO233828	GACA	ICGC	VITST	DEG_SPOP_SBC_1	0.6765
p.E3970K	DO222494	MELA	ICGC	VITST	DEG_SPOP_SBC_1	0.3056
p.G3959A	SIDM01449	Pancreatic Carcinoma	GDSC	VITST	DEG_SPOP_SBC_1	0.1667
p.G3959A	ACH-000517	Pancreatic Cancer	CCLE	VITST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	306:310	VITST	SPOP	0.8673	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3965:3969	VITST	SPOP	0.6873	More...
Q8TBN0	Guanine nucleotide exchange factor for Rab-3A	DEG_SPOP_SBC_1	161:165	VITST	SPOP	0.9826	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6333:6337	VITST	SPOP	0.9371	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8088:8092	VITST	SPOP	0.9495	More...
Q6AHZ1	Zinc finger protein 518A	DEG_SPOP_SBC_1	1207:1211	VITST	SPOP	0.8555	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons