DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 8088:8092

E3 ligase: SPOP

DEGRON score: 0.9495

ASA_SCORE: 83.3

COIL: 0.7482

CONS_SCORE: 0

DSS_SCORE: 0.4863

HELIX: 0.018

FCONS_SCORE: 0

RIG_SCORE: 0.7639

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D8095Y	TCGA-85-6798	LUSC	TCGA	VITST	DEG_SPOP_SBC_1	0.25
p.D8095Y	DO27295	LUSC	ICGC	VITST	DEG_SPOP_SBC_1	0.25
p.S8085Y	TCGA-CA-6718	COAD	TCGA	VITST	DEG_SPOP_SBC_1	0.25
p.S8085Y	DO7801	COAD	ICGC	VITST	DEG_SPOP_SBC_1	0.25
p.P8086S	TCGA-ER-A19M	SKCM	TCGA	VITST	DEG_SPOP_SBC_1	0.2778
p.P8086S	DO37798	SKCM	ICGC	VITST	DEG_SPOP_SBC_1	0.2778
p.S8081C	TCGA-VS-A94X	CESC	TCGA	VITST	DEG_SPOP_SBC_1	0.1389
p.S8081C	DO51632	CESC	ICGC	VITST	DEG_SPOP_SBC_1	0.1389
p.M8093T	DO234321	ESAD	ICGC	VITST	DEG_SPOP_SBC_1	0.3056
p.T8096S	DO234367	ESAD	ICGC	VITST	DEG_SPOP_SBC_1	0.2222
p.T8090N	DO229018	LICA	ICGC	VITST	DEG_SPOP_SBC_1	0.7055
p.S8081F	DO220885	MELA	ICGC	VITST	DEG_SPOP_SBC_1	0.1389
p.E8094K	DO222527	MELA	ICGC	VITST	DEG_SPOP_SBC_1	0.2778
p.M8093V	SIDM00569	Osteosarcoma	GDSC	VITST	DEG_SPOP_SBC_1	0.3056
p.M8093V	ACH-002178	Bone Cancer	CCLE	VITST	DEG_SPOP_SBC_1	0.3056
p.M8093V	NY	bone	COSMIC	VITST	DEG_SPOP_SBC_1	0.3056
p.M8087V	SIDM00254	Neuroblastoma	GDSC	VITST	DEG_SPOP_SBC_1	0.3056
p.M8087V	SIDM01445	Gastric Carcinoma	GDSC	VITST	DEG_SPOP_SBC_1	0.3056
p.M8087V	ACH-000736	Gastric Cancer	CCLE	VITST	DEG_SPOP_SBC_1	0.3056
p.M8087V	ACH-002283	Neuroblastoma	CCLE	VITST	DEG_SPOP_SBC_1	0.3056
p.M8087V	NB5	autonomic_ganglia	COSMIC	VITST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	306:310	VITST	SPOP	0.8673	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3965:3969	VITST	SPOP	0.6873	More...
Q8TBN0	Guanine nucleotide exchange factor for Rab-3A	DEG_SPOP_SBC_1	161:165	VITST	SPOP	0.9826	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6333:6337	VITST	SPOP	0.9371	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8088:8092	VITST	SPOP	0.9495	More...
Q6AHZ1	Zinc finger protein 518A	DEG_SPOP_SBC_1	1207:1211	VITST	SPOP	0.8555	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons