DegronMD

Uniprot ID: Q8NCR3

Source protein: Protein MFI

Source gene: MFI

Class: DEG_SCF_FBW7_1

Location: 305:310

E3 ligase: FBXW7

DEGRON score: 0.9824

ASA_SCORE: 69.3167

COIL: 0.8522

CONS_SCORE: 0.3021

DSS_SCORE: 0.7118

HELIX: 0.0863

FCONS_SCORE: 1.0061

RIG_SCORE: 0.7657

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P307H	TCGA-06-5416	GBM	TCGA	LTPDST	DEG_SCF_FBW7_1	0.7694
p.P307H	DO10880	GBM	ICGC	LTPDST	DEG_SCF_FBW7_1	0.7694
p.N295H	TCGA-AG-A002	READ	TCGA	LTPDST	DEG_SCF_FBW7_1	0.0556
p.N295H	TCGA-EO-A3AY	UCEC	TCGA	LTPDST	DEG_SCF_FBW7_1	0.0556
p.N295H	DO43202	UCEC	ICGC	LTPDST	DEG_SCF_FBW7_1	0.0556
p.T306M	TCGA-GV-A6ZA	BLCA	TCGA	LTPDST	DEG_SCF_FBW7_1	0.7423
p.T306M	DO49776	BLCA	ICGC	LTPDST	DEG_SCF_FBW7_1	0.7423
p.T306M	DO229389	BTCA	ICGC	LTPDST	DEG_SCF_FBW7_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NCR3	Protein MFI	DEG_SCF_FBW7_1	305:310	LTPDST	FBXW7	0.9824	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons