DegronMD

Uniprot ID: Q9H5I5

Source protein: Piezo-type mechanosensitive ion channel component 2

Source gene: PIEZO2

Class: DEG_SCF_FBW7_2

Location: 1809:1814

E3 ligase: FBXW7

DEGRON score: 0.6092

ASA_SCORE: 90.0667

COIL: 0.5503

CONS_SCORE: 0.3521

DSS_SCORE: 0.6326

HELIX: 0.3533

FCONS_SCORE: 1.1724

RIG_SCORE: 0.7396

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1820N	DO228948	LICA	ICGC	LTPEEE	DEG_SCF_FBW7_2	0.1667
p.D1822E	DO229029	LICA	ICGC	LTPEEE	DEG_SCF_FBW7_2	0.1111
p.A1801D	DO229009	LICA	ICGC	LTPEEE	DEG_SCF_FBW7_2	0.1111
p.D1824N	DO222908	MELA	ICGC	LTPEEE	DEG_SCF_FBW7_2	0.0556
p.L1815V	DO233366	RECA	ICGC	LTPEEE	DEG_SCF_FBW7_2	0.3056
p.G1823R	DO43210	UCEC	ICGC	LTPEEE	DEG_SCF_FBW7_2	0.0833
p.V1799L	ACH-000088	Non-Cancerous	CCLE	LTPEEE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H5I5	Piezo-type mechanosensitive ion channel component 2	DEG_SCF_FBW7_2	1809:1814	LTPEEE	FBXW7	0.6092	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons