DegronMD

Uniprot ID: Q7Z353

Source protein: Highly divergent homeobox

Source gene: HDX

Class: DEG_SCF_FBW7_2

Location: 523:528

E3 ligase: FBXW7

DEGRON score: 0.8093

ASA_SCORE: 84.2333

COIL: 0.9178

CONS_SCORE: 0.4302

DSS_SCORE: 0.8098

HELIX: 0.0318

FCONS_SCORE: 1.0071

RIG_SCORE: 0.591

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A529G	TCGA-05-4390	LUAD	TCGA	LTPGEE	DEG_SCF_FBW7_2	0.3056
p.E535D	TCGA-AG-A002	READ	TCGA	LTPGEE	DEG_SCF_FBW7_2	0.1389
p.E528K	TCGA-AX-A1CE	UCEC	TCGA	LTPGEE	DEG_SCF_FBW7_2	0.7022
p.E528K	DO42280	UCEC	ICGC	LTPGEE	DEG_SCF_FBW7_2	0.7022
p.G526V	TCGA-B6-A0RG	BRCA	TCGA	LTPGEE	DEG_SCF_FBW7_2	0.6421
p.G526V	DO2353	BRCA	ICGC	LTPGEE	DEG_SCF_FBW7_2	0.6421
p.L523P	TCGA-CK-5913	COAD	TCGA	LTPGEE	DEG_SCF_FBW7_2	0.6471
p.Q514E	TCGA-CN-5364	HNSC	TCGA	LTPGEE	DEG_SCF_FBW7_2	0.0833
p.E532K	TCGA-DA-A1HW	SKCM	TCGA	LTPGEE	DEG_SCF_FBW7_2	0.2222
p.E532K	DO38129	SKCM	ICGC	LTPGEE	DEG_SCF_FBW7_2	0.2222
p.E532D	TCGA-VQ-A91Z	STAD	TCGA	LTPGEE	DEG_SCF_FBW7_2	0.2222
p.E527D	DO222874	COCA	ICGC	LTPGEE	DEG_SCF_FBW7_2	0.5647
p.N537Y	DO219922	DLBC	ICGC	LTPGEE	DEG_SCF_FBW7_2	0.0833
p.P531T	DO229029	LICA	ICGC	LTPGEE	DEG_SCF_FBW7_2	0.25
p.G530R	DO229050	LICA	ICGC	LTPGEE	DEG_SCF_FBW7_2	0.2778
p.K523I	DO219197	LUSC	ICGC	LTPGEE	DEG_SCF_FBW7_2	0.7531
p.E531D	DO229453	SKCA	ICGC	LTPGEE	DEG_SCF_FBW7_2	0.25
p.D520Y	DO42713	UCEC	ICGC	LTPGEE	DEG_SCF_FBW7_2	0.25
p.I526N	DO43971	UCEC	ICGC	LTPGEE	DEG_SCF_FBW7_2	0.728
p.L523R	SIDM01285	Esophageal Carcinoma	GDSC	LTPGEE	DEG_SCF_FBW7_2	0.8428
p.S519F	SIDM01161	Other Sarcomas	GDSC	LTPGEE	DEG_SCF_FBW7_2	0.2222
p.S519F	ACH-001274	Sarcoma	CCLE	LTPGEE	DEG_SCF_FBW7_2	0.2222
p.S519F	SW982	soft_tissue	COSMIC	LTPGEE	DEG_SCF_FBW7_2	0.2222
p.D533N	CAL-148	breast	COSMIC	LTPGEE	DEG_SCF_FBW7_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z353	Highly divergent homeobox	DEG_SCF_FBW7_2	523:528	LTPGEE	FBXW7	0.8093	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons